Hep C NS3 Antibody (1828): sc-69938

Hep C NS3 Antibody (1828) is a mouse monoclonal IgG1 antibody that detects the Hep C NS3 protein of Hep C origin by western blotting (WB) and immunofluorescence (IF). Hep C NS3 (1828) antibody is available as the non-conjugated anti-Hep C NS3 antibody. The Hep C (Hepatitis C) virus is a small, enveloped, single-stranded, positive-sense RNA virus belonging to the family Flaviviridae, and poses significant health risks, including chronic infections, liver cirrhosis, and hepatocellular carcinoma. Hep C NS3 plays a crucial role in the virus′s life cycle, possessing both protease and helicase activities that are essential for viral replication and proliferation. The protease function of NS3 is vital for processing the viral polyprotein into functional proteins, while helicase activity unwinds RNA, facilitating replication. This dual functionality not only underscores NS3′s importance in the viral life cycle but also makes NS3 a potential target for antiviral therapies aimed at disrupting Hep C replication. Hep C primarily replicates within hepatocytes in the liver, where viral particles bind to specific receptors on the cell surface, allowing for entry and subsequent replication. The rapid replication of Hep C, producing approximately one trillion particles daily in infected individuals, is exacerbated by a high mutation rate due to the lack of proofreading by RNA polymerase, enabling viral evasion of host immune response.

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Hep C NS3 Antibody (1828) References:

1. The roles of hepatitis C virus proteins in modulation of cellular functions: a novel action mechanism of the HCV core protein on gene regulation by nuclear hormone receptors.  |  Watashi, K. and Shimotohno, K. 2003. Cancer Sci. 94: 937-43. PMID: 14611668
2. Detection and quantitation of HCV core protein in single hepatocytes by means of laser capture microdissection and enzyme-linked immunosorbent assay.  |  Sansonno, D., et al. 2004. J Viral Hepat. 11: 27-32. PMID: 14738555
3. Nucleic acid binding properties and intermediates of HCV core protein multimerization in Pichia pastoris.  |  Acosta-Rivero, N., et al. 2004. Biochem Biophys Res Commun. 323: 926-31. PMID: 15381089
4. Morphological alteration and biological properties of hepatocytes not related to tumorigenesis following transfection with HCV core protein.  |  Gu, J., et al. 2005. J Viral Hepat. 12: 20-6. PMID: 15655044
5. Profiles of HCV core protein and viremia in chronic hepatitis C: possible protective role of core antigen in liver damage.  |  Carabaich, A., et al. 2005. J Med Virol. 76: 55-60. PMID: 15778969
6. HCV core protein augments cyclosporine immunosuppression.  |  Kimball, P., et al. 2005. Transplant Proc. 37: 652-3. PMID: 15848490
7. Thr 446 phosphorylation of PKR by HCV core protein deregulates G2/M phase in HCC cells.  |  Alisi, A., et al. 2005. J Cell Physiol. 205: 25-31. PMID: 15880455
8. Hepatitis C virus (HCV) core protein enhances the immunogenicity of a co-delivered DNA vaccine encoding HCV structural antigens in mice.  |  Alvarez-Lajonchere, L., et al. 2006. Biotechnol Appl Biochem. 44: 9-17. PMID: 16367740
9. Designing and analysis of a potent bi-functional aptamers that inhibit protease and helicase activities of HCV NS3.  |  Umehara, T., et al. 2004. Nucleic Acids Symp Ser (Oxf). 195-6. PMID: 17150545

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Hep C NS3 Antibody (1828) has 6 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Hep C NS3 Antibody (1828) Specifications

Alternate Product Name: Hep C NS3

Product Clone Name: 1828

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: Hep C NS3

Epitope Species: Hepatitis C

Product Reactivity/Detection: NS3 genotypes 1a, 2a and 2c

Species Reactivity/Detection: Hep C

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IF

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide, 0.1% gelatin and < 0.1% stabilizer protein

Research Citations: 6 citations in various scientific publications

Available Conjugates/Forms for Hep C NS3 Antibody (1828): N/A