Hep C E1 Antibody (1879): sc-65459

Hep C E1 Antibody (1879) is a mouse monoclonal IgG1 antibody that detects Hep C E1 protein of Hep C origin by western blotting (WB), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). Anti-Hep C E1 antibody (1879) is available as a non-conjugated format. Hep C E1 protein is a crucial component of the hepatitis C virus, a small, enveloped, single-stranded, positive-sense RNA virus belonging to the Flaviviridae family. Hep C E1 protein plays a significant role in virus entry into host cells through E1E2 heterodimer formation, which enables viral entry and fusion with host cell membranes. Hep C E1 protein′s structure, characterized by transmembrane domains, facilitates proper folding and stability of the E1E2 complex, enhancing viral infectivity. Understanding Hep C E1 protein is important for developing therapeutic strategies and vaccines against hepatitis C, as this target for neutralizing antibodies plays a key role in viral life cycles. Hep C infection can lead to severe health complications, including chronic liver disease, cirrhosis, and hepatocellular carcinoma, making Hep C E1 protein study and interactions critical for public health.

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Hep C E1 Antibody (1879) References:

1. The roles of hepatitis C virus proteins in modulation of cellular functions: a novel action mechanism of the HCV core protein on gene regulation by nuclear hormone receptors.  |  Watashi, K. and Shimotohno, K. 2003. Cancer Sci. 94: 937-43. PMID: 14611668
2. Detection and quantitation of HCV core protein in single hepatocytes by means of laser capture microdissection and enzyme-linked immunosorbent assay.  |  Sansonno, D., et al. 2004. J Viral Hepat. 11: 27-32. PMID: 14738555
3. Nucleic acid binding properties and intermediates of HCV core protein multimerization in Pichia pastoris.  |  Acosta-Rivero, N., et al. 2004. Biochem Biophys Res Commun. 323: 926-31. PMID: 15381089
4. Morphological alteration and biological properties of hepatocytes not related to tumorigenesis following transfection with HCV core protein.  |  Gu, J., et al. 2005. J Viral Hepat. 12: 20-6. PMID: 15655044
5. Profiles of HCV core protein and viremia in chronic hepatitis C: possible protective role of core antigen in liver damage.  |  Carabaich, A., et al. 2005. J Med Virol. 76: 55-60. PMID: 15778969
6. HCV core protein augments cyclosporine immunosuppression.  |  Kimball, P., et al. 2005. Transplant Proc. 37: 652-3. PMID: 15848490
7. Thr 446 phosphorylation of PKR by HCV core protein deregulates G2/M phase in HCC cells.  |  Alisi, A., et al. 2005. J Cell Physiol. 205: 25-31. PMID: 15880455
8. HCV core protein promotes liver fibrogenesis via up-regulation of CTGF with TGF-beta1.  |  Shin, JY., et al. 2005. Exp Mol Med. 37: 138-45. PMID: 15886528
9. Hepatitis C virus (HCV) core protein enhances the immunogenicity of a co-delivered DNA vaccine encoding HCV structural antigens in mice.  |  Alvarez-Lajonchere, L., et al. 2006. Biotechnol Appl Biochem. 44: 9-17. PMID: 16367740

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Hep C E1 Antibody (1879) has 7 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Hep C E1 Antibody (1879) Specifications

Alternate Product Name: Hep C E1

Product Clone Name: 1879

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: Hep C E1

Epitope Species: Hepatitis C virus

Product Reactivity/Detection: E1 genotypes 1a and 1b

Species Reactivity/Detection: Hep C

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IF, IHC(P)

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 7 citations in various scientific publications

Available Conjugates/Forms for Hep C E1 Antibody (1879): N/A