Hep C cAg Antibody (1851): sc-58144
- Hep C cAg Antibody (1851) is a mouse monoclonal IgG1, cited in 1 publications, provided at 100 µg/ml
- raised against Hep C
- recommended for detection of an epitope corresponding to amino acids 29-39 of core antigen of Hep C origin by WB, IP, IF and IHC(P)
- See Hep C cAg (C7-50): sc-57800 for Hep C cAg antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Hep C cAg Antibody (1851). This work is in progress.
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Hep C cAg Antibody (1851) is a mouse monoclonal IgG1 antibody that detects Hep C cAg in Hepatitis C virus by applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). Hep C cAg plays a crucial role in the life cycle of the Hepatitis C virus, as a structural protein that forms the viral core, encapsulating the viral RNA and proteins. Hep C cAg (1851) antibody targets a protein essential for the assembly and release of new viral particles, making Hep C cAg a key target for therapeutic interventions and vaccine development. Conservation of Hep C cAg across different viral genotypes highlights Hep C cAg′s importance in the virus′s ability to persist and evade the host immune response, as well as potential role in the pathogenesis of liver disease. Understanding Hep C cAg function is vital, as Hep C cAg may contribute to hepatic fibrogenesis by up-regulating connective tissue growth factor and transforming growth factor beta 1, which are involved in liver scarring and fibrosis. Anti-Hep C cAg antibody (1851) serves as an invaluable tool for researchers studying the mechanisms of Hepatitis C infection and associated liver complications.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Hep C cAg Antibody (1851) References:
- HCV core protein induces hepatic lipid accumulation by activating SREBP1 and PPARgamma. | Kim, KH., et al. 2007. Biochem Biophys Res Commun. 355: 883-8. PMID: 17331464
- HCV core protein interacts with Dicer to antagonize RNA silencing. | Chen, W., et al. 2008. Virus Res. 133: 250-8. PMID: 18325616
- HCV core protein promotes heparin binding EGF-like growth factor expression and activates Akt. | Nakamura, H., et al. 2011. Hepatol Res. 41: 455-62. PMID: 21418450
- HCV core protein-induced down-regulation of microRNA-152 promoted aberrant proliferation by regulating Wnt1 in HepG2 cells. | Huang, S., et al. 2014. PLoS One. 9: e81730. PMID: 24416131
- Down-regulation of PTEN by HCV core protein through activating nuclear factor-κB. | Zhang, Y., et al. 2014. Int J Clin Exp Pathol. 7: 7351-9. PMID: 25550771
- HCV core protein uses multiple mechanisms to induce oxidative stress in human hepatoma Huh7 cells. | Ivanov, AV., et al. 2015. Viruses. 7: 2745-70. PMID: 26035647
- HCV core protein represses the apoptosis and improves the autophagy of human hepatocytes. | Liu, C., et al. 2015. Int J Clin Exp Med. 8: 15787-93. PMID: 26629077
- HCV core protein-induced upregulation of microRNA-196a promotes aberrant proliferation in hepatocellular carcinoma by targeting FOXO1. | Xu, H., et al. 2016. Mol Med Rep. 13: 5223-9. PMID: 27108614
- HCV core protein binds to gC1qR to induce A20 expression and inhibit cytokine production through MAPKs and NF-κB signaling pathways. | Song, X., et al. 2016. Oncotarget. 7: 33796-808. PMID: 27183919
- Hepatitis B Virus X Protein Stimulates Hepatitis C Virus (HCV) Replication by Protecting HCV Core Protein from E6AP-Mediated Proteasomal Degradation. | Yoon, H., et al. 2022. Microbiol Spectr. 10: e0143222. PMID: 36374094
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Hep C cAg Antibody (1851) | sc-58144 | 100 µg/ml | $322.00 |