Hemoglobin ζ Antibody (C-1B3): sc-101272

Hemoglobin ζ Antibody (C-1B3) is a mouse monoclonal IgG1 kappa light chain antibody that detects Hemoglobin zeta protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-Hemoglobin zeta antibody (C-1B3) is available as the non-conjugated form. Hemoglobin, a crucial protein in the body, is responsible for transporting oxygen from the lungs to tissues and facilitating the return of carbon dioxide from tissues back to the lungs. Hemoglobin zeta protein plays a significant role during embryonic development, particularly in the yolk sac stage, where expression occurs before the switch to adult hemoglobin forms. This early expression is vital for ensuring that the developing embryo receives adequate oxygen supply during a critical period of growth. The protein′s structure, which consists of two alpha and two zeta chains, allows for the formation of a tetramer that can effectively bind oxygen. The unique properties of the zeta chain, including its interaction with heme groups, contribute to the overall functionality of hemoglobin in oxygen transport. Understanding the role of Hemoglobin zeta is essential for studying various hematological disorders and developmental biology, making Hemoglobin ζ monoclonal antibody (C-1B3) a valuable tool for researchers in these fields.

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Hemoglobin ζ Antibody (C-1B3) References:

1. Assembly of human hemoglobin (Hb) beta- and gamma-globin chains expressed in a cell-free system with alpha-globin chains to form Hb A and Hb F.  |  Adachi, K., et al. 2002. J Biol Chem. 277: 13415-20. PMID: 11827978
2. Linkage of interactions in sickle hemoglobin fiber assembly: inhibitory effect emanating from mutations in the AB region of the alpha-chain is annulled by a mutation at its EF corner.  |  Sudha, R., et al. 2004. J Biol Chem. 279: 20018-27. PMID: 14982923
3. Transfer of human alpha- to beta-hemoglobin via its chaperone protein: evidence for a new state.  |  Baudin-Creuza, V., et al. 2004. J Biol Chem. 279: 36530-3. PMID: 15220346
4. Molecular mechanism of AHSP-mediated stabilization of alpha-hemoglobin.  |  Feng, L., et al. 2004. Cell. 119: 629-40. PMID: 15550245
5. Effect of zeta-globin substitution on the O2-transport properties of Hb S in vitro and in vivo.  |  He, Z. and Russell, JE. 2004. Biochem Biophys Res Commun. 325: 1376-82. PMID: 15555579
6. Verrucous hemangioma expresses primitive markers.  |  Laing, EL., et al. 2013. J Cutan Pathol. 40: 391-6. PMID: 23379586
7. 3,3',5-Triiodothyroacetic acid (TRIAC) induces embryonic ζ-globin expression via thyroid hormone receptor α.  |  Chen, H., et al. 2021. J Hematol Oncol. 14: 99. PMID: 34174920
8. Quantification of human embryonic ζ-globin chains in Southeast Asian deletion (--SEA) carriers.  |  Ye, Y., et al. 2023. J Clin Pathol. 76: 784-789. PMID: 36008105
9. Molecular basis of length polymorphism in the human zeta-globin gene complex.  |  Goodbourn, SE., et al. 1983. Proc Natl Acad Sci U S A. 80: 5022-6. PMID: 6308667
10. Homology and concerted evolution at the alpha 1 and alpha 2 loci of human alpha-globin.  |  Liebhaber, SA., et al. 1981. Nature. 290: 26-9. PMID: 7010180
11. The multiple functions of hemoglobin.  |  Giardina, B., et al. 1995. Crit Rev Biochem Mol Biol. 30: 165-96. PMID: 7555018
12. Hb E and alpha-thalassemia; variability in the assembly of beta E chain containing tetramers.  |  Huisman, TH. 1997. Hemoglobin. 21: 227-36. PMID: 9140719

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Hemoglobin ζ Antibody (C-1B3) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Hemoglobin ζ Antibody (C-1B3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Hemoglobin ζ Antibody (C-1B3) Specifications

Alternate Product Name: Hemoglobin zeta (HBZ)

Product Clone Name: C-1B3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-143

Epitope Target: Hemoglobin ζ

Epitope Species: human

Product Reactivity/Detection: Hemoglobin ζ

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Hemoglobin ζ Antibody (C-1B3): N/A