Hemoglobin α Antibody (B-10): sc-514851

Hemoglobin α Antibody (B-10) is a mouse monoclonal IgM antibody that detects Hemoglobin α in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Hemoglobin α plays a crucial role in oxygen transport within the bloodstream, as it forms a vital component of the hemoglobin tetramer alongside Hemoglobin β. Hemoglobin α is primarily located in red blood cells, where it binds to oxygen in the lungs and releases it in tissues, a process essential for cellular respiration and energy production. The structure of Hemoglobin α, which consists of a single polypeptide chain that folds into a globular shape, allows for precise interaction with heme groups, enabling efficient oxygen binding. Additionally, post-translational modifications, such as phosphorylation and glycosylation, can influence the stability and function of Hemoglobin α, impacting oxygen transport efficiency. Anti-Hemoglobin α antibody (B-10) is an invaluable tool for researchers studying hemoglobinopathies and related disorders, providing insights into the molecular mechanisms underlying oxygen transport and its regulation in human physiology.

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Hemoglobin α Antibody (B-10) References:

1. Neurons express hemoglobin alpha- and beta-chains in rat and human brains.  |  Richter, F., et al. 2009. J Comp Neurol. 515: 538-47. PMID: 19479992
2. AGH is a new hemoglobin alpha-chain fragment with antinociceptive activity.  |  Ribeiro, NM., et al. 2013. Peptides. 48: 10-20. PMID: 23911313
3. Hemoglobin α/eNOS coupling at myoendothelial junctions is required for nitric oxide scavenging during vasoconstriction.  |  Straub, AC., et al. 2014. Arterioscler Thromb Vasc Biol. 34: 2594-600. PMID: 25278292
4. Targeting Pulmonary Endothelial Hemoglobin α Improves Nitric Oxide Signaling and Reverses Pulmonary Artery Endothelial Dysfunction.  |  Alvarez, RA., et al. 2017. Am J Respir Cell Mol Biol. 57: 733-744. PMID: 28800253
5. Regulation of endothelial hemoglobin alpha expression by Kruppel-like factors.  |  Sangwung, P., et al. 2017. Vasc Med. 22: 363-369. PMID: 28825355
6. Hemoglobin-α-synuclein complex exhibited age-dependent alterations in the human striatum and peripheral RBCs.  |  Yang, W., et al. 2020. Neurosci Lett. 736: 135274. PMID: 32712351
7. Stability of Maleimide-PEG and Mono-Sulfone-PEG Conjugation to a Novel Engineered Cysteine in the Human Hemoglobin Alpha Subunit.  |  Cooper, CE., et al. 2021. Front Chem. 9: 707797. PMID: 34381760
8. New Intracellular Peptide Derived from Hemoglobin Alpha Chain Induces Glucose Uptake and Reduces Blood Glycemia.  |  Silva, RNO., et al. 2021. Pharmaceutics. 13: PMID: 34959456
9. Hemoglobin α-derived peptides VD-hemopressin (α) and RVD-hemopressin (α) are involved in electroacupuncture inhibition of chronic pain.  |  Yuan, X., et al. 2024. Front Pharmacol. 15: 1439448. PMID: 39411061
10. Duplication of structural genes for hemoglobin alpha and beta chains in man.  |  Rucknagel, DL. and Winter, WP. 1974. Ann N Y Acad Sci. 241: 80-92. PMID: 4611311

The preferred Hemoglobin α antibody is Hemoglobin α Antibody (D-4): sc-514378.