Molecular structure of HEMADO, CAS Number: 403842-38-6
HEMADO (CAS 403842-38-6)
Alternate Names:
2-(1-Hexynyl)-N-methyladenosine
Application:
HEMADO is a high affinity and selective Adenosine A3-R agonist
CAS Number:
403842-38-6
Purity:
≥95%
Molecular Weight:
361.39
Molecular Formula:
C17H23N5O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
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Description
Technical Information
Safety Information
SDS & Certificate of Analysis
High affinity selective A3 agonist
HEMADO (CAS 403842-38-6) References
- N(6)-alkyl-2-alkynyl derivatives of adenosine as potent and selective agonists at the human adenosine A(3) receptor and a starting point for searching A(2B) ligands. | Volpini, R., et al. 2002. J Med Chem. 45: 3271-9. PMID: 12109910
- [3H]HEMADO--a novel tritiated agonist selective for the human adenosine A3 receptor. | Klotz, KN., et al. 2007. Eur J Pharmacol. 556: 14-8. PMID: 17126322
- International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and classification of adenosine receptors--an update. | Fredholm, BB., et al. 2011. Pharmacol Rev. 63: 1-34. PMID: 21303899
- Disparity in FcεRI-induced degranulation of primary human lung and skin mast cells exposed to adenosine. | Gomez, G., et al. 2011. J Clin Immunol. 31: 479-87. PMID: 21437670
- Reciprocal modulation of anti-IgE induced histamine release from human mast cells by A₁ and A(2B) adenosine receptors. | Yip, KH., et al. 2011. Br J Pharmacol. 164: 807-19. PMID: 21506953
- Discovery of purinergic signalling, the initial resistance and current explosion of interest. | Burnstock, G. 2012. Br J Pharmacol. 167: 238-55. PMID: 22537142
- Chalcone-based derivatives as new scaffolds for hA3 adenosine receptor antagonists. | Vazquez-Rodriguez, S., et al. 2013. J Pharm Pharmacol. 65: 697-703. PMID: 23600387
- Concurrent agonism of adenosine A2B and glucocorticoid receptors in human airway epithelial cells cooperatively induces genes with anti-inflammatory potential: a novel approach to treat chronic obstructive pulmonary disease. | Greer, S., et al. 2013. J Pharmacol Exp Ther. 346: 473-85. PMID: 23820127
- Effect of HEMADO on Level of CK-MB and LDH Enzymes after Ischemia/Reperfusion Injury in Isolated Rat Heart. | Amani, M., et al. 2013. Bioimpacts. 3: 101-4. PMID: 23878794
- Structure-Activity Analysis of Biased Agonism at the Human Adenosine A3 Receptor. | Baltos, JA., et al. 2016. Mol Pharmacol. 90: 12-22. PMID: 27136943
- A binding kinetics study of human adenosine A3 receptor agonists. | Xia, L., et al. 2018. Biochem Pharmacol. 153: 248-259. PMID: 29305857
- Antioxidant-Conjugated 1,2,4-Triazolo[4,3-a]pyrazin-3-one Derivatives: Highly Potent and Selective Human A2A Adenosine Receptor Antagonists Possessing Protective Efficacy in Neuropathic Pain. | Falsini, M., et al. 2019. J Med Chem. 62: 8511-8531. PMID: 31453698
- Anti-Inflammatory Effects of Endogenously Released Adenosine in Synovial Cells of Osteoarthritis and Rheumatoid Arthritis Patients. | Sohn, R., et al. 2021. Int J Mol Sci. 22: PMID: 34445661
Activator of:
Adenosine A Receptor, and Adenosine A3-R.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HEMADO, 10 mg | sc-203595 | 10 mg | $205.00 | |||
| US: Only available in the US | ||||||
HEMADO, 50 mg | sc-203595A | 50 mg | $865.00 | |||
| US: Only available in the US | ||||||