Date published: 2026-4-9

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Helvolic acid (CAS 29400-42-8)

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Alternate Names:
Fumigacin
Application:
Helvolic acid is a mycotoxin with antibacterial activity
CAS Number:
29400-42-8
Molecular Weight:
568.70
Molecular Formula:
C33H44O8
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Helvolic acid is a compound that functions as an inhibitor of certain enzymes involved in cellular processes. It exerts its mechanism of action by binding to the active site of the target enzyme, thereby preventing the substrate from binding and inhibiting the enzyme′s activity. This inhibition disrupts specific biochemical pathways, leading to downstream effects on cellular function. Helvolic acid′s mechanism of action involves interfering with the synthesis of cellular components, ultimately impacting cell growth and proliferation. It may exhibit antimicrobial activity by disrupting the integrity of bacterial cell membranes. Helvolic acid is utilized to investigate the molecular pathways and cellular processes affected by its inhibitory properties.


Helvolic acid (CAS 29400-42-8) References

  1. Conspecificity of the cerulenin and helvolic acid producing 'Cephalosporium caerulens', and the hypocrealean fungus Sarocladium oryzae.  |  Bills, GF., et al. 2004. Mycol Res. 108: 1291-300. PMID: 15587062
  2. Identification of novel derivative of helvolic acid from Metarhizium anisopliae grown in medium with insect component.  |  Lee, SY., et al. 2008. J Biosci Bioeng. 105: 476-80. PMID: 18558337
  3. In vitro synergistic antibacterial activities of helvolic acid on multi-drug resistant Staphylococcus aureus.  |  Qin, L., et al. 2009. Nat Prod Res. 23: 309-18. PMID: 19296371
  4. Preparative separation of helvolic acid from the endophytic fungus Pichia guilliermondii Ppf9 by high-speed counter-current chromatography.  |  Zhao, J., et al. 2012. World J Microbiol Biotechnol. 28: 835-40. PMID: 22805802
  5. Helvolic acid, an antibacterial nortriterpenoid from a fungal endophyte, Xylaria sp. of orchid Anoectochilus setaceus endemic to Sri Lanka.  |  Ratnaweera, PB., et al. 2014. Mycology. 5: 23-28. PMID: 24772371
  6. De novo genome assembly and annotation of rice sheath rot fungus Sarocladium oryzae reveals genes involved in Helvolic acid and Cerulenin biosynthesis pathways.  |  Hittalmani, S., et al. 2016. BMC Genomics. 17: 271. PMID: 27036298
  7. Synergistic antitumor efficacy of antibacterial helvolic acid from Cordyceps taii and cyclophosphamide in a tumor mouse model.  |  Xiao, JH., et al. 2017. Exp Biol Med (Maywood). 242: 214-222. PMID: 27604096
  8. Biosynthesis of helvolic acid and identification of an unusual C-4-demethylation process distinct from sterol biosynthesis.  |  Lv, JM., et al. 2017. Nat Commun. 8: 1644. PMID: 29158519
  9. Helvolic acid attenuates osteoclast formation and function via suppressing RANKL-induced NFATc1 activation.  |  Chen, K., et al. 2019. J Cell Physiol. 234: 6477-6488. PMID: 30341897
  10. Morphological, Pathogenic and Toxigenic Variability in the Rice Sheath Rot Pathogen Sarocladium Oryzae.  |  Peeters, KJ., et al. 2020. Toxins (Basel). 12: PMID: 32046323
  11. Production of Helvolic Acid in Metarhizium Contributes to Fungal Infection of Insects by Bacteriostatic Inhibition of the Host Cuticular Microbiomes.  |  Sun, Y., et al. 2022. Microbiol Spectr. 10: e0262022. PMID: 36047778
  12. Studies on microbial products. I. Helvolic acid and related compounds. I. 7-desacetoxyhelvolic acid and helvolinic acid.  |  Okuda, S., et al. 1966. Chem Pharm Bull (Tokyo). 14: 436-41. PMID: 5939322

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Helvolic acid, 1 mg

sc-396538
1 mg
$250.00