Hellebrin CAS: 13289-18-4
MF: C36H52O15
MW: 724.8
A cardiotonic bufadienolide-steroid glycoside.

Hellebrin (CAS 13289-18-4)

Hellebrin | CAS 13289-18-4 is rated 5.0 out of 5 by 1.
  • y_2021, m_1, d_18, h_21
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.12
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_202645, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 108ms
  • REVIEWS, PRODUCT
5
1
4
0
3
0
2
0
1
0
Alternate Names: 3β-(O4-β-D-Glucopyranosyl-α-L-rhamnopyranosyloxy)-5,14-dihydroxy-19-oxo-5β,14-β-bufa-20,22-dienolide
Application: Hellebrin is a cardiotonic bufadienolide-steroid glycoside
CAS Number: 13289-18-4
Purity: ≥99%
Molecular Weight: 724.8
Molecular Formula: C36H52O15
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Hellebrin is a cardiotonic glycoside which presents a bufadienolide-steroid structure. Besides ouabain, from the class of cardenolides hellebrin is the second unique water soluble cardiotonic glycoside. Extremely potent inhibitor of Na+/K+-ATPase (sodium pump) blocking the active efflux of Na+ and reuptake of K+ of this membrane enzyme. Shows a positive inotropic effect by increasing the intracellular Ca2+ concentration. Hellebrin is a strong immunosuppressor inhibiting T cell activity with much higher potency than cortisol or cyclosporin A Induces caspase-dependent apoptosis.


References

Über Hellebrin, ein krystallisiertes Glykosid aus Radix Hellebori nigri: W. Karrer; Helv. Chim. Acta 26, 1353 (1943) The structure of hellebrin: P. Muhr, et al.; Liebigs Ann. Org. Bioorg. Chem. 2, 443 (1995) In search of ideal inotropic steroids: recent progress: K.R. Repke, et al.; Prog. Drug Res. 47, 9 (1996) Exquisitely small amounts of nonglucocorticoid natural steroids suppress the human allogeneic T-cell response: P. Terness, et al.; Transplant Proc. 33, 547 (2001) Apoptosis-mediated selective killing of malignant cells by cardiac steroids: maintenance of cytotoxicity and loss of cardiac activity of chemically modified derivatives: D. Daniel, et al.; Int. Immunopharmacol. 3, 1791 (2003)

Physical State :
Solid
Derived From :
Helleborus sp.
Solubility :
Soluble in water (4.4 mg/ml).
Storage :
Store at -20° C
Boiling Point :
930.99° C at 760 mmHg (Predicted)
Density :
1.50 g/cm3 (Predicted)
Refractive Index :
n20D 1.65 (Predicted)
IC50 :
Hs683: IC50 = 7 nM (human); A549: IC50 = 16 nM (human); U373 : IC50 = 49 nM (human); MCF7: IC50 = 82 nM (human); CT26: IC50 >10 µM (mouse)
pK Values :
pKa: 12.89 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
441859
MDL Number :
MFCD03265649
EC Number :
236-303-1

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

Hello, I'm a veterinary medicine and pharmacology toxicology doctoral student in Turkey. I'm working on development hellebrin HPLC-DAD methods. Please, Can you share me your's hellebrin hplc methods? Best regards.

Asked by: onurdemirvet
Thank you for your question. We are not able to share our HPLC methods with you for this research chemical.
Answered by: Technical Support
Date published: 2017-12-07

Hello- Do you have 5 mg quantities of Hellebrin (sc-202645) in stock? Thank you

Asked by: TimB
Thank you for your question. Please contact our Customer Care team to inquire about current product availability. Please call us toll-free at (800) 457-3801 option 1, or email [email protected], or use our live chat on our website!
Answered by: Technical Support
Date published: 2017-02-08
  • y_2021, m_1, d_18, h_21CST
  • bvseo_bulk, prod_bvqa, vn_bulk_3.0.12
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_2
  • loc_en_US, sid_202645, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 118ms
  • QUESTIONS, PRODUCT
Rated 5 out of 5 by from Moreno et al Moreno et al. (PubMed ID 23621895) found that hellebrin inhibited cancer growth by binding to 2 1 and 3 1 Na/K ATPase complexes. -SCBT Publication Review
Date published: 2015-04-20
  • y_2021, m_1, d_18, h_21
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.12
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_202645, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 6ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2021 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.