Molecular structure of Heliquinomycin, CAS Number: 178182-49-5
Heliquinomycin (CAS 178182-49-5)
Alternate Names:
Rubymycin
Application:
Heliquinomycin is a DNA helicase inhibitor
CAS Number:
178182-49-5
Molecular Weight:
698.58
Molecular Formula:
C33H30O17
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Heliquinomycin is a DNA helicase inhibitor. Heliquinomycin inhibits the DNA helicase activity of the human minichromosome maintenance (MCM) 4/6/7 complex. It is also an antibiotic and anticancer compound. Heliquinomycin is an antibacterial against Gram-positive bacteria.
Heliquinomycin (CAS 178182-49-5) References
- Flavones inhibit the hexameric replicative helicase RepA. | Xu, H., et al. 2001. Nucleic Acids Res. 29: 5058-66. PMID: 11812837
- The Total Synthesis of Heliquinomycinone This work was supported by the National Institutes of Health (Grant numbers: AI 16943 and HL25848). The authors thank Dr. Makoto Chino of Nippon Kayaku Co., Ltd. for kindly providing a sample of heliquinomycin, and Yashuiro Itagaki of Columbia University for high-resolution mass spectral analyses. | Siu, T., et al. 2001. Angew Chem Int Ed Engl. 40: 4713-4716. PMID: 12404392
- Synthesis of bisbenzannulated spiroketals-model studies for a modular approach to rubromycins. | Sörgel, S., et al. 2006. Org Lett. 8: 4875-8. PMID: 17020325
- Cleavage of four carbon-carbon bonds during biosynthesis of the griseorhodin a spiroketal pharmacophore. | Yunt, Z., et al. 2009. J Am Chem Soc. 131: 2297-305. PMID: 19175308
- Effect of heliquinomycin on the activity of human minichromosome maintenance 4/6/7 helicase. | Ishimi, Y., et al. 2009. FEBS J. 276: 3382-91. PMID: 19438708
- Interaction of heliquinomycin with single-stranded DNA inhibits MCM4/6/7 helicase. | Sugiyama, T., et al. 2012. J Biochem. 151: 129-37. PMID: 22023799
- Isolation, biological activity, biosynthesis and synthetic studies towards the rubromycin family of natural products. | Atkinson, DJ. and Brimble, MA. 2015. Nat Prod Rep. 32: 811-40. PMID: 25798711
- Characterization of Streptomyces piniterrae sp. nov. and Identification of the Putative Gene Cluster Encoding the Biosynthesis of Heliquinomycins. | Zhuang, X., et al. 2020. Microorganisms. 8: PMID: 32244447
- Heliquinomycin, a new inhibitor of DNA helicase, produced by Streptomyces sp. MJ929-SF2 I. Taxonomy, production, isolation, physico-chemical properties and biological activities. | Chino, M., et al. 1996. J Antibiot (Tokyo). 49: 752-7. PMID: 8823506
- Heliquinomycin, a new inhibitor of DNA helicase, produced by Streptomyces sp. MJ929-SF2 II. Structure determination of heliquinomycin. | Chino, M., et al. 1997. J Antibiot (Tokyo). 50: 143-6. PMID: 9099224
- Heliquinomycin, a new inhibitor of DNA helicase, produced by Streptomyces sp. MJ929-SF2. III. Biosynthesis. | Chino, M., et al. 1997. J Antibiot (Tokyo). 50: 781-4. PMID: 9360626
- Effect of a novel antibiotic, heliquinomycin, on DNA helicase and cell growth. | Chino, M., et al. 1998. J Antibiot (Tokyo). 51: 480-6. PMID: 9666176
- Alkoxyallene-Based De Novo Synthesis of Rare Deoxy Sugars: New Routes to L-Cymarose, L-Sarmentose, L-Diginose and L-Oleandrose | and Malte Brasholz, Hans-Ulrich Reißig. July 2009. European Journal of Organic Chemistry. Volume2009, Issue21: Pages 3595-3604.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Heliquinomycin, 250 µg | sc-396502 | 250 µg | $325.00 | |||
Heliquinomycin, 500 µg | sc-396502A | 500 µg | $525.00 |