HECTD1 Antibody (1E10): sc-517169
- HECTD1 Antibody (1E10) is a mouse monoclonal IgG2b κ HECTD1 antibody, cited in 1 publications, provided at 100 µg/ml
- raised against amino acids 3-110 representing partial length HECTD1 of human origin
- recommended for detection of HECTD1 of mouse, rat and human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for HECTD1 Antibody (1E10). This work is in progress.
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HECTD1 Antibody (1E10) is a mouse monoclonal IgG2b kappa light chain antibody that detects HECTD1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-HECTD1 antibody (1E10) is available as a non-conjugated monoclonal isotype antibody. HECTD1, also known as EULIR (E3 ubiquitin-protein ligase for inhibin receptor), plays a crucial role as an E3 ubiquitin ligase within the ubiquitin-proteasome system, which is essential for regulating protein degradation and maintaining cellular homeostasis. HECTD1 is responsible for the transfer of ubiquitin to specific substrate proteins, a process vital for various cellular functions, including cell cycle regulation, signal transduction, and DNA repair. HECTD1 features a unique structure that includes an N-terminal ankyrin repeat domain, a mind bomb (mib) domain, and a C-terminal HECT domain, with the latter being critical for ubiquitin ligase activity, facilitating the polyubiquitination of target proteins. HECTD1 is expressed throughout early development and is particularly important for proper closure of the neural tube; mutations in the gene encoding HECTD1 can lead to severe neural tube defects, highlighting its significance in embryonic development and overall organismal health.
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HECTD1 Antibody (1E10) References:
- Methods for the functional genomic analysis of ubiquitin ligases. | Li, W., et al. 2005. Methods Enzymol. 398: 280-91. PMID: 16275336
- Different HECT domain ubiquitin ligases employ distinct mechanisms of polyubiquitin chain synthesis. | Wang, M. and Pickart, CM. 2005. EMBO J. 24: 4324-33. PMID: 16341092
- Differential expression in histologically normal crypts of ulcerative colitis suggests primary crypt disorder. | Kim, M., et al. 2006. Oncol Rep. 16: 663-70. PMID: 16969477
- Dietary trans 10, cis 12-conjugated linoleic acid reduces the expression of fatty acid oxidation and drug detoxification enzymes in mouse liver. | Rasooly, R., et al. 2007. Br J Nutr. 97: 58-66. PMID: 17217560
- G2E3 is a nucleo-cytoplasmic shuttling protein with DNA damage responsive localization. | Brooks, WS., et al. 2007. Exp Cell Res. 313: 665-76. PMID: 17239372
- Regulation of catalytic activities of HECT ubiquitin ligases. | Kee, Y. and Huibregtse, JM. 2007. Biochem Biophys Res Commun. 354: 329-33. PMID: 17240353
- The Hectd1 ubiquitin ligase is required for development of the head mesenchyme and neural tube closure. | Zohn, IE., et al. 2007. Dev Biol. 306: 208-21. PMID: 17442300
- Structural basis of ubiquitin recognition by the ubiquitin-associated (UBA) domain of the ubiquitin ligase EDD. | Kozlov, G., et al. 2007. J Biol Chem. 282: 35787-95. PMID: 17897937
- Molecular pathways associated with stress resilience and drug resistance in the chronic mild stress rat model of depression: a gene expression study. | Bergström, A., et al. 2007. J Mol Neurosci. 33: 201-15. PMID: 17917079
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HECTD1 Antibody (1E10) | sc-517169 | 100 µg/ml | $322.00 |