Molecular structure of Hecogenin Acetate, CAS Number: 915-35-5
Hecogenin Acetate (CAS 915-35-5)
CAS Number:
915-35-5
Purity:
≥90%
Molecular Weight:
472.7
Molecular Formula:
C29H44O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Hecogenin acetate is a compound that attracts interest in the field of biochemistry, particularly in the exploration of steroidal structure-activity relationships. This molecule is an acetylated form of hecogenin, a sapogenin found in plants like Agave sisalana. In research, it is utilized to understand the subtle changes in molecular structure that affect the biological function of steroids. Its role as an intermediate in the synthesis of hormonally active compounds allows scientists to dissect the pathways and mechanisms by which steroids exert their effects at the molecular level. Moreover, hecogenin acetate is instrumental in the study of steroidal alkaloids and glycosides.
Hecogenin Acetate (CAS 915-35-5) References
- Synthesis of C14,15-dihydro-C22,25-epi north unit of cephalostatin 1 via 'red-ox' modifications of hecogenin acetate. | Lee, S., et al. 2009. Org Lett. 11: 5-8. PMID: 19055428
- Synthesis of 14',15'-dehydro-ritterazine Y via reductive and oxidative functionalizations of hecogenin acetate. | Kou, Y., et al. 2013. Steroids. 78: 304-11. PMID: 23238516
- Evidence for the involvement of descending pain-inhibitory mechanisms in the antinociceptive effect of hecogenin acetate. | Gama, KB., et al. 2013. J Nat Prod. 76: 559-63. PMID: 23437926
- Synthesis of C17-OH-north unit of ritterazine G via 'Red-Ox' modifications of hecogenin acetate. | Cheun, Y., et al. 2013. Steroids. 78: 639-43. PMID: 23500411
- Evidence for the involvement of spinal cord-inhibitory and cytokines-modulatory mechanisms in the anti-hyperalgesic effect of hecogenin acetate, a steroidal sapogenin-acetylated, in mice. | Quintans, JS., et al. 2014. Molecules. 19: 8303-16. PMID: 24950436
- Hecogenin acetate inhibits reactive oxygen species production and induces cell cycle arrest and senescence in the A549 human lung cancer cell line. | Gasparotto, J., et al. 2014. Anticancer Agents Med Chem. 14: 1128-35. PMID: 25115457
- Synthesis of 23-deoxy-25-epi north unit of cephalostatin 1 via reductive and oxidative modifications of hecogenin acetate. | Kumar, RN. and Lee, S. 2017. Steroids. 118: 68-75. PMID: 28041952
- Inclusion complex between β-cyclodextrin and hecogenin acetate produces superior analgesic effect in animal models for orofacial pain. | Carvalho, YMBG., et al. 2017. Biomed Pharmacother. 93: 754-762. PMID: 28704800
- Amorphous solid dispersions of hecogenin acetate using different polymers for enhancement of solubility and improvement of anti-hyperalgesic effect in neuropathic pain model in mice. | de França Almeida Moreira, CDL., et al. 2018. Biomed Pharmacother. 97: 870-879. PMID: 29136763
- Role of peripheral and central sensitization in the anti-hyperalgesic effect of hecogenin acetate, an acetylated sapogenin, complexed with β-cyclodextrin: Involvement of NFκB and p38 MAPK pathways. | Santos Passos, FR., et al. 2021. Neuropharmacology. 186: 108395. PMID: 33516738
- Synthesis of 5α,6-Dihydroveragranines A and B. | Zhu, LC., et al. 2022. Org Lett. 24: 5825-5828. PMID: 35920688
- Evaluation of the antibacterial activity of hecogenin acetate and its inhibitory potential of NorA and MepA efflux pumps from Staphylococcus aureus. | Santos Araújo, NJ., et al. 2023. Microb Pathog. 174: 105925. PMID: 36462578
- Antiulcerogenic and healing activity of hecogenin acetate in rodents. | Sousa, AJC., et al. 2023. Naunyn Schmiedebergs Arch Pharmacol. 396: 759-769. PMID: 36474020
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Hecogenin Acetate, 5 g | sc-295139 | 5 g | $195.00 |