Molecular structure of Hecogenin, CAS Number: 467-55-0
Hecogenin (CAS 467-55-0)
See product citations (2)
CAS Number:
467-55-0
Purity:
≥80%
Molecular Weight:
430.62
Molecular Formula:
C27H42O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Hecogenin is a sapogenin found in agave plants and is the focus of extensive research due to its role as a chemical precursor in the synthesis of steroid compounds. It is employed as a starting material in organic synthesis, where chemists use it to explore various pathways for creating complex steroids that are of interest for their structural and functional diversity. The compound is also a subject of investigation in the field of biochemistry, where its role in the biosynthesis of steroids within plants is examined to understand the intricate web of plant metabolism. In materials science, researchers are interested in the properties of hecogenin-based compounds for the creation of bioactive materials.
Hecogenin (CAS 467-55-0) References
- On the formation of 4-[N,N-bis(2-chloroethyl)amino]phenyl acetic acid esters of hecogenin and aza-homo-hecogenin and their antileukemic activity. | Camoutsis, C., et al. 2005. Farmaco. 60: 826-9. PMID: 16139280
- Selectivity of substrate (trifluoperazine) and inhibitor (amitriptyline, androsterone, canrenoic acid, hecogenin, phenylbutazone, quinidine, quinine, and sulfinpyrazone) 'probes' for human udp-glucuronosyltransferases. | Uchaipichat, V., et al. 2006. Drug Metab Dispos. 34: 449-56. PMID: 16381668
- Inhibition of human rheumatoid arthritis synovial cell survival by hecogenin and tigogenin is associated with increased apoptosis, p38 mitogen-activated protein kinase activity and upregulation of cyclooxygenase-2. | Liagre, B., et al. 2007. Int J Mol Med. 20: 451-60. PMID: 17786275
- Effects of hecogenin and its possible mechanism of action on experimental models of gastric ulcer in mice. | Santos Cerqueira, G., et al. 2012. Eur J Pharmacol. 683: 260-9. PMID: 22426163
- Evidence for the involvement of descending pain-inhibitory mechanisms in the antinociceptive effect of hecogenin acetate. | Gama, KB., et al. 2013. J Nat Prod. 76: 559-63. PMID: 23437926
- Evidence for the involvement of spinal cord-inhibitory and cytokines-modulatory mechanisms in the anti-hyperalgesic effect of hecogenin acetate, a steroidal sapogenin-acetylated, in mice. | Quintans, JS., et al. 2014. Molecules. 19: 8303-16. PMID: 24950436
- Anti-Inflammatory Potential of Hecogenin in Experimental Animals: Possible Involvement of Inflammatory Cytokines and Myeloperoxidase. | Ingawale, DK. and Patel, SS. 2016. Drug Res (Stuttg). 66: 644-656. PMID: 27684191
- Effect of Hecogenin on DNA instability. | Cruz, MS., et al. 2016. Toxicol Rep. 3: 539-543. PMID: 28959577
- Rationally designed hecogenin thiosemicarbazone analogs as novel MEK inhibitors for the control of breast malignancies. | Elsayed, HE., et al. 2017. Bioorg Med Chem. 25: 6297-6312. PMID: 29066046
- Hecogenin exhibits anti-arthritic activity in rats through suppression of pro-inflammatory cytokines in Complete Freund's adjuvant-induced arthritis. | Ingawale, DK. and Patel, SS. 2018. Immunopharmacol Immunotoxicol. 40: 59-71. PMID: 29192804
- Anti-inflammatory potential of hecogenin on atopic dermatitis and airway hyper-responsiveness by regulation of pro-inflammatory cytokines. | Ingawale, DK., et al. 2019. Immunopharmacol Immunotoxicol. 41: 327-336. PMID: 31039648
- Hecogenin and fluticasone combination attenuates TNBS-induced ulcerative colitis in rats via downregulation of pro-inflammatory mediators and oxidative stress. | Ingawale, DK., et al. 2021. Immunopharmacol Immunotoxicol. 43: 160-170. PMID: 33435764
- Hecogenin and its derivates: A pharmacology review. | Borges, MADH., et al. 2023. Biomed Pharmacother. 159: 114251. PMID: 36641922
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Hecogenin, 100 mg | sc-295138 | 100 mg | $56.00 | |||
Hecogenin, 1 g | sc-295138A | 1 g | $254.00 |