HDSF (CAS 86855-26-7)
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HDSF, or hexadecylsulfonyl fluoride, is a compound utilized in biochemical research primarily for its role as a serine protease inhibitor. By inhibiting serine proteases, HDSF is instrumental in studying the function and regulation of these enzymes, which are involved in many physiological processes. The use of HDSF in research helps to prevent unwanted proteolysis during protein extraction and purification, thereby preserving the integrity of proteins for further analysis. Additionally, HDSF is employed in mechanistic studies to explore the role of serine proteases in disease pathogenesis and to identify potential targets for intervention. Its application extends to the examination of protease-mediated signaling pathways and the modulation of these pathways in various cellular contexts.
HDSF (CAS 86855-26-7) References
- Structural basis for the insensitivity of a serine enzyme (palmitoyl-protein thioesterase) to phenylmethylsulfonyl fluoride. | Das, AK., et al. 2000. J Biol Chem. 275: 23847-51. PMID: 10801859
- Monoglyceride lipase-like enzymatic activity is responsible for hydrolysis of 2-arachidonoylglycerol in rat cerebellar membranes. | Saario, SM., et al. 2004. Biochem Pharmacol. 67: 1381-7. PMID: 15013854
- Human fatty acid synthase: structure and substrate selectivity of the thioesterase domain. | Chakravarty, B., et al. 2004. Proc Natl Acad Sci U S A. 101: 15567-72. PMID: 15507492
- Lipid chain selectivity by outer membrane phospholipase A. | Stanley, AM., et al. 2007. J Mol Biol. 366: 461-8. PMID: 17174333
- Visualization of 2-arachidonoylglycerol accumulation and cannabinoid CB1 receptor activity in rat brain cryosections by functional autoradiography. | Palomäki, VA., et al. 2007. J Neurochem. 101: 972-81. PMID: 17254014
- A novel monoacylglycerol lipase inhibitor with analgesic and anti-inflammatory activity. | Magrioti, V., et al. 2008. Bioorg Med Chem Lett. 18: 5424-7. PMID: 18819796
- Inactivation of Escherichia coli outer-membrane phospholipase A by the affinity label hexadecanesulfonyl fluoride. Evidence for an active-site serine. | Horrevoets, AJ., et al. 1991. Eur J Biochem. 198: 247-53. PMID: 2040286
- Activation of reconstituted Escherichia coli outer-membrane phospholipase A by membrane-perturbing peptides results in an increased reactivity towards the affinity label hexadecanesulfonyl fluoride. | Horrevoets, AJ., et al. 1991. Eur J Biochem. 198: 255-61. PMID: 2040288
- Chemical approaches to therapeutically target the metabolism and signaling of the endocannabinoid 2-AG and eicosanoids. | Kohnz, RA. and Nomura, DK. 2014. Chem Soc Rev. 43: 6859-69. PMID: 24676249
- Fatty Acyl Sulfonyl Fluoride as an Activity-Based Probe for Profiling Fatty Acid-Associated Proteins in Living Cells. | Zhang, D., et al. 2022. Chembiochem. 23: e202100628. PMID: 34918441
- Inactivation of Staphylococcus hyicus lipase by hexadecylsulfonyl fluoride: evidence for an active site serine. | Leuveling Tjeenk, M., et al. 1994. Protein Eng. 7: 579-83. PMID: 8029215
- Escherichia coli outer membrane phospholipase A: role of two serines in enzymatic activity. | Brok, RG., et al. 1996. Biochemistry. 35: 7787-93. PMID: 8672479
- Role of Pseudomonas aeruginosa lipase in inflammatory mediator release from human inflammatory effector cells (platelets, granulocytes, and monocytes. | König, B., et al. 1996. Infect Immun. 64: 3252-8. PMID: 8757861
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HDSF, 25 mg | sc-221708 | 25 mg | $84.00 | |||
HDSF, 100 mg | sc-221708A | 100 mg | $302.00 |