HCTU (CAS 330645-87-9)
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HCTU is an organophosphorus compound extensively utilized as a reagent in the synthesis of various organic molecules, including peptides and nucleic acids. Additionally, it has proven instrumental in the synthesis of small organic molecules like dyes and fluorescent probes. This colorless, crystalline solid remains stable under standard storage conditions and exhibits solubility in polar organic solvents like dimethyl sulfoxide (DMSO) and dimethylformamide (DMF). The exact mechanism of action of HCTU is not entirely elucidated however, it is believed to involve the formation of a covalent bond between the phosphate group of HCTU and the substrate molecule. This covalent bond is subsequently cleaved by a base, such as sodium hydroxide, resulting in the release of the desired product.
HCTU (CAS 330645-87-9) References
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- New heterocyclic beta-sheet ligands with peptidic recognition elements. | Rzepecki, P., et al. 2004. J Org Chem. 69: 5168-78. PMID: 15287758
- Fast conventional Fmoc solid-phase peptide synthesis with HCTU. | Hood, CA., et al. 2008. J Pept Sci. 14: 97-101. PMID: 17890639
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- Development of a novel gene silencer pyrrole-imidazole polyamide targeting human connective tissue growth factor. | Wan, JX., et al. 2011. Biol Pharm Bull. 34: 1572-7. PMID: 21963497
- Fast conventional Fmoc solid-phase peptide synthesis: a comparative study of different activators. | Chantell, CA., et al. 2012. J Pept Sci. 18: 88-91. PMID: 22147296
- Evaluation of COMU as a coupling reagent for in situ neutralization Boc solid phase peptide synthesis. | Hjørringgaard, CU., et al. 2012. J Pept Sci. 18: 199-207. PMID: 22252935
- New α-adrenergic property for synthetic MTβ and CM-3 three-finger fold toxins from black mamba. | Blanchet, G., et al. 2013. Toxicon. 75: 160-7. PMID: 23648423
- COMU: scope and limitations of the latest innovation in peptide acyl transfer reagents. | Subirós-Funosas, R., et al. 2013. J Pept Sci. 19: 408-14. PMID: 23712932
- Anaphylaxis Induced by Peptide Coupling Agents: Lessons Learned from Repeated Exposure to HATU, HBTU, and HCTU. | McKnelly, KJ., et al. 2020. J Org Chem. 85: 1764-1768. PMID: 31849224
- Solid-Phase Synthesis of Octapeptin Lipopeptides. | Hansford, KA., et al. 2020. Methods Mol Biol. 2103: 199-213. PMID: 31879927
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HCTU, 5 g | sc-252871 | 5 g | $38.00 | |||
HCTU, 25 g | sc-252871A | 25 g | $123.00 |