CD44 Antibody (IRAWB 14.4): sc-65876
- CD44 Antibody (IRAWB 14.4) is a rat monoclonal IgG2a, cited in 1 publications, provided at 200 µg/ml
- raised against an HA-binding varient of a T-cell line derived from a spontaneous tumor of mouse origin
- recommended for detection of HCAM of mouse origin by FCMIHC(P)
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- See CD44 (DF1485): sc-7297 for CD44 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for CD44 Antibody (IRAWB 14.4). This work is in progress.
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HCAM Antibody (IRAWB 14.4) is a rat monoclonal IgG2a antibody that detects HCAM in mouse samples through applications such as flow cytometry (FCM) and immunohistochemistry with paraffin-embedded sections (IHCP). HCAM, also known as CD44, is a 742 amino acid single-pass type I membrane protein that plays a crucial role in cell adhesion and migration, which are vital processes in embryogenesis, immune response, and tumor metastasis. HCAM (IRAWB 14.4) antibody recognizes a protein that functions as a receptor for hyaluronic acid (HA) and interacts with various ligands, including osteopontin (OPN), facilitating both cell-cell and cell-matrix interactions. HCAM expression is particularly significant in cancer, as one isoform, CD44H, appears at elevated levels in tumor tissues, indicating potential involvement in tumor progression and metastasis. HCAM undergoes alternative splicing, resulting in multiple isoforms such as CD44R, CDw44, CD44S, and CD44E, which are differentially expressed across various tissues. HCAM-mediated interactions underscore a significant role in maintaining cellular architecture and influencing cellular behavior in both normal and pathological states.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CD44 Antibody (IRAWB 14.4) References:
- CD44-mediated neutrophil apoptosis in the rat. | Takazoe, K., et al. 2000. Kidney Int. 58: 1920-30. PMID: 11044212
- Hyaluronidase can modulate expression of CD44. | Stern, R., et al. 2001. Exp Cell Res. 266: 167-76. PMID: 11339835
- CD44 Presence in inflamed pulp tissue. | Pisterna, GV. and Siragusa, M. 2007. J Endod. 33: 1203-7. PMID: 17889690
- CD44 deficiency attenuates chronic murine ileitis. | Collins, CB., et al. 2008. Gastroenterology. 135: 1993-2002. PMID: 18854186
- Involvement of hyaluronan and its receptor CD44 with choroidal neovascularization. | Mochimaru, H., et al. 2009. Invest Ophthalmol Vis Sci. 50: 4410-5. PMID: 19339747
- PTK7 regulates Id1 expression in CD44-high glioma cells. | Liu, Q., et al. 2015. Neuro Oncol. 17: 505-15. PMID: 25204555
- CD44 variant, but not standard CD44 isoforms, mediate disassembly of endothelial VE-cadherin junction on metastatic melanoma cells. | Zhang, P., et al. 2014. FEBS Lett. 588: 4573-82. PMID: 25447529
- CD44+ fibroblasts increases breast cancer cell survival and drug resistance via IGF2BP3-CD44-IGF2 signalling. | Liu, Y., et al. 2017. J Cell Mol Med. 21: 1979-1988. PMID: 28523716
- Conventional Treatment of Glioblastoma Reveals Persistent CD44+ Subpopulations. | Gudbergsson, JM., et al. 2020. Mol Neurobiol. 57: 3943-3955. PMID: 32632605
- CD44 splice variants: metastases meet lymphocytes. | Herrlich, P., et al. 1993. Immunol Today. 14: 395-9. PMID: 7691067
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD44 Antibody (IRAWB 14.4) | sc-65876 | 200 µg/ml | $322.00 | |||
CD44 Antibody (IRAWB 14.4) FITC | sc-65876 FITC | 200 µg/ml | $336.00 | |||
CD44 Antibody (IRAWB 14.4) PE | sc-65876 PE | 200 µg/ml | $349.00 |