CD44 Antibody (156-3C11): sc-59909
- CD44 Antibody (156-3C11) is a mouse monoclonal IgG2a, cited in 2 publications, provided at 200 µg/ml
- raised against stimulated leukocytes of human origin
- recommended for detection of HCAM of human origin by WB, IP, IF and IHC(P)
- See CD44 (DF1485): sc-7297 for CD44 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG2a BP-HRP is the preferred secondary detection reagent for CD44 Antibody (156-3C11) for WB and IHC(P) applications. This reagent is now offered in a bundle with CD44 Antibody (156-3C11) (see ordering information below).
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HCAM Antibody (156-3C11) is a mouse monoclonal IgG2a antibody that detects HCAM in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. HCAM, also known as CD44, is a 742 amino acid single-pass type I membrane protein that plays a crucial role in cell adhesion and migration, which are vital processes in embryogenesis, immune response, and tumor metastasis. HCAM functions as a receptor for hyaluronic acid (HA) and interacts with ligands such as osteopontin (OPN), facilitating both cell-cell and cell-matrix interactions. The significance of HCAM′s structure lies in its Link domain and the presence of multiple isoforms generated through alternative splicing, including CD44R, CDw44, CD44S, CD44H, and CD44E. The CD44H isoform is highly expressed in cancer tissues, indicating potential involvement in tumor progression and making HCAM a critical target for cancer research. Anti-HCAM antibody (156-3C11) provides valuable insights into the dynamics of cell adhesion and migration, serving as an essential tool for researchers studying hematopoiesis, lymphocyte activation, and the mechanisms underlying tumor metastasis.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CD44 Antibody (156-3C11) References:
- The emerging role of CD44 in regulating skeletal micrometastasis. | Hill, A., et al. 2006. Cancer Lett. 237: 1-9. PMID: 15979783
- Proteomic identification of CD44 interacting proteins. | Skandalis, SS., et al. 2010. IUBMB Life. 62: 833-40. PMID: 21117172
- Role of CD44 in the organization of keratinocyte pericellular hyaluronan. | Pasonen-Seppänen, S., et al. 2012. Histochem Cell Biol. 137: 107-20. PMID: 22072421
- Interactions between Hyaluronan and Its Receptors (CD44, RHAMM) Regulate the Activities of Inflammation and Cancer. | Misra, S., et al. 2015. Front Immunol. 6: 201. PMID: 25999946
- Whether CD44 is an applicable marker for glioma stem cells. | Wang, HH., et al. 2017. Am J Transl Res. 9: 4785-4806. PMID: 29218080
- CD44(+) tumor cells promote early angiogenesis in head and neck squamous cell carcinoma. | Ludwig, N., et al. 2019. Cancer Lett. 467: 85-95. PMID: 31593802
- Structural Constraint of Osteopontin Facilitates Efficient Binding to CD44. | Fnu, G., et al. 2021. Biomolecules. 11: PMID: 34070790
- Identification of microRNA expression profiles of CD44+ ovarian cancer stem cells. | Wang, L., et al. 2022. Arch Gynecol Obstet. 306: 461-472. PMID: 35076757
- Cisplatin-Resistant CD44+ Lung Cancer Cells Are Sensitive to Auger Electrons. | Madsen, KL., et al. 2022. Int J Mol Sci. 23: PMID: 35806135
- CD44 and hyaluronan binding by human myeloid cells. | Smadja-Joffe, F., et al. 1996. Leuk Lymphoma. 21: 407-20, color plates following 528. PMID: 9172805
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD44 Antibody (156-3C11) | sc-59909 | 200 µg/ml | $322.00 | |||
CD44 Antibody (156-3C11): m-IgG2a BP-HRP Bundle | sc-552937 | 200 µg Ab; 10 µg BP | $361.00 |