Molecular structure of HC 067047, CAS Number: 883031-03-6
HC 067047 (CAS 883031-03-6)
See product citations (9)
Alternate Names:
2-Methyl-1-[3-(4-morpholinyl)propyl]-5-phenyl-N-[3-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide
Application:
HC 067047 is a selective and potent TRPV4 antagonist
CAS Number:
883031-03-6
Purity:
≥98%
Molecular Weight:
471.51
Molecular Formula:
C26H28F3N3O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
HC 067047 is a selective and potent TRPV4 antagonist. This compound has been found to reversibly inhibit currents through mouse, human and rat TRPV4 orthologs. Additional data suggests that HC 067047 inhibits the endogenous TRPV4-mediated response to 4-alphaPDH. HC-067047, a potent and selective TRPV4 antagonist, effectively inhibits TRPV4-mediated responses in mice, humans, and rats, with IC50 values of 17, 48, and 133 nM, respectively.
HC 067047 (CAS 883031-03-6) References
- Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis. | Everaerts, W., et al. 2010. Proc Natl Acad Sci U S A. 107: 19084-9. PMID: 20956320
- TRPA1 and TRPV4 mediate paclitaxel-induced peripheral neuropathy in mice via a glutathione-sensitive mechanism. | Materazzi, S., et al. 2012. Pflugers Arch. 463: 561-9. PMID: 22258694
- TRPV4 channel contributes to serotonin-induced pulmonary vasoconstriction and the enhanced vascular reactivity in chronic hypoxic pulmonary hypertension. | Xia, Y., et al. 2013. Am J Physiol Cell Physiol. 305: C704-15. PMID: 23739180
- Transient receptor potential vanilloid 4 mediates hypotonicity-induced enhancement of synaptic transmission in hippocampal slices. | Li, L., et al. 2013. CNS Neurosci Ther. 19: 854-62. PMID: 23826708
- TRPV4 activates autonomic and behavioural warmth-defence responses in Wistar rats. | Vizin, RC., et al. 2015. Acta Physiol (Oxf). 214: 275-89. PMID: 25739906
- Blockage of transient receptor potential vanilloid 4 inhibits brain edema in middle cerebral artery occlusion mice. | Jie, P., et al. 2015. Front Cell Neurosci. 9: 141. PMID: 25914628
- Blockage of transient receptor potential vanilloid 4 alleviates myocardial ischemia/reperfusion injury in mice. | Dong, Q., et al. 2017. Sci Rep. 7: 42678. PMID: 28205608
- TRPV4-induced inflammatory response is involved in neuronal death in pilocarpine model of temporal lobe epilepsy in mice. | Wang, Z., et al. 2019. Cell Death Dis. 10: 386. PMID: 31097691
- The selective TRPV4 channel antagonist HC-067047 attenuates mechanical allodynia in diabetic mice. | Dias, FC., et al. 2019. Eur J Pharmacol. 856: 172408. PMID: 31129158
- Blockade of Transient Receptor Potential Vanilloid 4 Enhances Antioxidation after Myocardial Ischemia/Reperfusion. | Wu, Q., et al. 2019. Oxid Med Cell Longev. 2019: 7283683. PMID: 31308876
- PIEZO1 and TRPV4, which Are Distinct Mechano-Sensors in the Osteoblastic MC3T3-E1 Cells, Modify Cell-Proliferation. | Yoneda, M., et al. 2019. Int J Mol Sci. 20: PMID: 31597314
- Modification of TRPV4 activity by acetaminophen. | Nakagawa, F., et al. 2020. Heliyon. 6: e03301. PMID: 32051870
- Involvement of TRPV4 in changes in rapidly inactivating potassium channels in the early stage of pilocarpine-induced status epilepticus in mice. | Xu, W., et al. 2022. J Cell Physiol. 237: 856-867. PMID: 34415059
- Pharmacological Inhibition of Transient Receptor Potential Vanilloid 4 Reduces Vasogenic Edema after Traumatic Brain Injury in Mice. | Michinaga, S., et al. 2021. Biol Pharm Bull. 44: 1759-1766. PMID: 34719652
- Ketamine administration ameliorates anesthesia and surgery-induced cognitive dysfunction via activation of TRPV4 channel opening. | Li, Q., et al. 2022. Exp Ther Med. 24: 478. PMID: 35761804
Inhibitor of:
TRPV3, and TRPV4.Activator of:
VRL-1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HC 067047, 10 mg | sc-361204 | 10 mg | $213.00 | |||
HC 067047, 50 mg | sc-361204A | 50 mg | $824.00 |