HBP1 Antibody (cl. 65): sc-56682
- HBP1 Antibody (cl. 65) is a mouse monoclonal IgG1 provided at 100 µl supernatant
- raised against HBP1 of human origin
- recommended for detection of HBP1 of mouse, rat and human origin by WB
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for HBP1 Antibody (cl. 65). This work is in progress.
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HBP1 Antibody (cl. 65) is a mouse monoclonal IgG1 antibody that detects HBP1 of mouse, rat, and human origin by western blotting (WB). Anti-HBP1 antibody (cl. 65) is available as the non-conjugated form. The high mobility group box protein 1 (HBP1) plays a crucial role in regulating gene expression and cell differentiation, acting as a transcription factor that binds to specific DNA sequences. Located primarily in the nucleus, HBP1 is essential for initiating cell cycle arrest, which is a prerequisite for terminal differentiation. This process is vital for the proper development of various tissues, as HBP1 interacts with tumor suppressor proteins such as Rb and p130 to halt cell proliferation. Furthermore, HBP1′s activity is intricately linked to the MyoD family of transcription factors, which are pivotal in muscle cell differentiation. By modulating the expression of tissue-specific genes, HBP1 ensures that cells commit to their specialized functions. The balance between HBP1 activity and MyoD-induced gene transcription is critical for the progression of terminal differentiation, highlighting HBP1′s importance in developmental biology and potential implications in cancer research.
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HBP1 Antibody (cl. 65) References:
- HBP1 promoter methylation augments the oncogenic β-catenin to correlate with prognosis in NSCLC. | Tseng, RC., et al. 2014. J Cell Mol Med. 18: 1752-61. PMID: 24895061
- HBP1 phosphorylation by AKT regulates its transcriptional activity and glioblastoma cell proliferation. | Bollaert, E., et al. 2018. Cell Signal. 44: 158-170. PMID: 29355710
- HBP1-mediated transcriptional repression of AFP inhibits hepatoma progression. | Cao, Z., et al. 2021. J Exp Clin Cancer Res. 40: 118. PMID: 33794968
- Methylation of HBP1 by PRMT1 promotes tumor progression by regulating actin cytoskeleton remodeling. | Wang, J., et al. 2022. Oncogenesis. 11: 45. PMID: 35941115
- The transcription factor HBP1 promotes ferroptosis in tumor cells by regulating the UHRF1-CDO1 axis. | Yang, R., et al. 2023. PLoS Biol. 21: e3001862. PMID: 37406020
- Targeting of HBP1/TIMP3 axis as a novel strategy against breast cancer. | Zhou, Y., et al. 2023. Pharmacol Res. 194: 106846. PMID: 37414199
- Expression cloning in K+ transport defective yeast and distribution of HBP1, a new putative HMG transcriptional regulator. | Lesage, F., et al. 1994. Nucleic Acids Res. 22: 3685-8. PMID: 7937077
- The regulation of myogenin gene expression during the embryonic development of the mouse. | Yee, SP. and Rigby, PW. 1993. Genes Dev. 7: 1277-89. PMID: 8391506
- HBP1: a HMG box transcriptional repressor that is targeted by the retinoblastoma family. | Tevosian, SG., et al. 1997. Genes Dev. 11: 383-96. PMID: 9030690
- The HMG-box transcription factor HBP1 is targeted by the pocket proteins and E1A. | Lavender, P., et al. 1997. Oncogene. 14: 2721-8. PMID: 9178770
- Regulation of differentiation by HBP1, a target of the retinoblastoma protein. | Shih, HH., et al. 1998. Mol Cell Biol. 18: 4732-43. PMID: 9671483
- MyD genes in negative growth control. | Liebermann, DA. and Hoffman, B. 1998. Oncogene. 17: 3319-29. PMID: 9916994
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HBP1 Antibody (cl. 65) | sc-56682 | 100 µl supernatant | $322.00 |