HBED CAS: 35369-53-0
MF: C20H24N2O6•HCl
MW: 424.89
An iron chelator and hydroxyl radical inhibitor.

HBED (CAS 35369-53-0)

HBED | CAS 35369-53-0 is rated 5.0 out of 5 by 1.
  • y_2020, m_4, d_6, h_14
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.5
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_200817, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 203ms
  • REVIEWS, PRODUCT
5
1
4
0
3
0
2
0
1
0
Synonym: N,N'-Di(2-hydroxybenzyl)ethylenediamine-N,N'-diacetic acid monohydrochloride
Application: An iron chelator and hydroxyl radical inhibitor
CAS Number: 35369-53-0
Molecular Weight: 424.89
Molecular Formula: C20H24N2O6•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

HBED, or hydroxybenzyl ethylenediamine, is a potent iron chelating compound. Through complexation with ferric ions, HBED is described to facilitate Fe(II) oxidation and to block O2(.-)-induced reduction of Fe(III), consequently blocking the Fe-mediated formation of hydroxyl radicals. HBED has been utilized as a tool for studying the involvement of hydroxyl radicals in cellular processes. HBED has specifically demonstrated to inhibit H2O2-induced apoptosis in neutrophils, suggesting participation of hydroxyl radicals in the mediation of neutrophilic apoptosis.


References

1. Hershko, C., et al. 1984. J. Lab. Clin. Med. 103: 337-346. PMID: 6699459
2. Rollet-Labelle, E., et al. 1998. Free Radic. Biol. Med. 24: 563-572. PMID: 9559868
3. Gozin, A., et al. 1998. Free Radic. Biol. Med. 25: 1021-1032. PMID: 9870555
4. Faller, B., et al. 2000. J. Med. Chem. 43: 1467-1475. PMID: 10780902
5. Samuni, A.M., et al. 2001. Free Radic. Biol. Med. 30: 170-177. PMID: 11163534

Physical State :
Solid
Solubility :
Soluble in DMSO (25 mg/ml), ethanol (25 mg/ml) at 40° C, and water (4 mg/ml) at 50° C (with vigorous agitation approximately 15 minutes).
Storage :
Store at room temperature
Refractive Index :
n20D 1.65
pK Values :
pKa: 1.77, 8.03
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
66848913
MDL Number :
MFCD04113603
SMILES :
C1=CC=C(C(=C1)CN(CCN(CC2=CC=CC=C2O)CC(=O)O)CC(=O)O)O.Cl

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 108ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of 5 by from Samuni et al Samuni et al. (PubMed ID 11163534) showed that HBED was a hydrogen-donating antioxidant and an effective iron chelator. -SCBT Publication Review
Date published: 2015-02-20
  • y_2020, m_4, d_6, h_14
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.5
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_200817, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 27ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2020 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.