Molecular structure of HBED, CAS Number: 35369-53-0
HBED (CAS 35369-53-0)
See product citations (2)
Alternate Names:
N,N′-Di(2-hydroxybenzyl)ethylenediamine-N,N′-diacetic acid monohydrochloride
Application:
HBED is an iron chelator and hydroxyl radical inhibitor
CAS Number:
35369-53-0
Molecular Weight:
424.89
Molecular Formula:
C20H24N2O6•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
HBED, or hydroxybenzyl ethylenediamine, is a potent iron chelating compound. Through complexation with ferric ions, HBED is described to facilitate Fe(II) oxidation and to block O2(.-)-induced reduction of Fe(III), consequently blocking the Fe-mediated formation of hydroxyl radicals. HBED has been utilized as a tool for studying the involvement of hydroxyl radicals in cellular processes. It has specifically demonstrated to inhibit H2O2-induced apoptosis in neutrophils, suggesting participation of hydroxyl radicals in the mediation of neutrophilic apoptosis.
HBED (CAS 35369-53-0) References
- Improving the oral bioavailability of the iron chelator HBED by breaking the symmetry of the intramolecular H-bond network. | Faller, B., et al. 2000. J Med Chem. 43: 1467-75. PMID: 10780902
- Multifunctional antioxidant activity of HBED iron chelator. | Samuni, AM., et al. 2001. Free Radic Biol Med. 30: 170-7. PMID: 11163534
- Phenolic ethylenediamine derivatives: a study of orally effective iron chelators. | Hershko, C., et al. 1984. J Lab Clin Med. 103: 337-46. PMID: 6699459
- Hydroxyl radical as a potential intracellular mediator of polymorphonuclear neutrophil apoptosis. | Rollet-Labelle, E., et al. 1998. Free Radic Biol Med. 24: 563-72. PMID: 9559868
- Reactive oxygen species activate focal adhesion kinase, paxillin and p130cas tyrosine phosphorylation in endothelial cells. | Gozin, A., et al. 1998. Free Radic Biol Med. 25: 1021-32. PMID: 9870555
Inhibitor of:
Apoptosis.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HBED, 50 mg | sc-200817 | 50 mg | $73.00 | |||
HBED, 250 mg | sc-200817A | 250 mg | $230.00 | |||
HBED, 1 g | sc-200817B | 1 g | $374.00 |