HBDDE (CAS 154675-18-0)
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HBDDE is a chemical compound of interest in the field of biochemical research due to its selective inhibition of Protein Kinase C (PKC) α and γ isotypes. This selectivity is significant as PKC is a family of enzymes that play critical roles in signal transduction pathways, regulating a variety of cellular processes including proliferation, differentiation, and apoptosis. The ability of HBDDE to inhibit specific PKC isotypes allows researchers to study the nuanced roles of these enzymes in cellular signaling. It is used in signal transduction research to dissect the pathways affected by PKC α and γ, providing insights into how these pathways can be modulated. Furthermore, HBDDE serves as a tool in cell biology for understanding the isoform-specific functions of PKC, which is essential for unraveling the complex regulatory mechanisms in cells. Additionally, its use can help delineate the contribution of PKC to various physiological and pathological processes, which may be important in the context of conditions where altered PKC activity is implicated.
HBDDE (CAS 154675-18-0) References
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- 2,2',3,3',4,4'-Hexahydroxy-1,1'-biphenyl-6,6'-dimethanol dimethyl ether (HBDDE)-induced neuronal apoptosis independent of classical protein kinase C alpha or gamma inhibition. | Mathur, A. and Vallano, ML. 2000. Biochem Pharmacol. 60: 809-15. PMID: 10930535
- Protein kinase Calpha mediates the effect of antiarrhythmic peptide on gap junction conductance. | Dhein, S., et al. 2001. Cell Commun Adhes. 8: 257-64. PMID: 12064599
- Alpha-tocopherol decreases superoxide anion release in human monocytes under hyperglycemic conditions via inhibition of protein kinase C-alpha. | Venugopal, SK., et al. 2002. Diabetes. 51: 3049-54. PMID: 12351446
- Protein kinase Calpha participates in activation of store-operated Ca2+ channels in human glomerular mesangial cells. | Ma, R., et al. 2002. Am J Physiol Cell Physiol. 283: C1390-8. PMID: 12372800
- Mechanisms of action of melanin-concentrating hormone in the teleost fish erythrophoroma cell line (GEM-81). | Isoldi, MC., et al. 2004. Gen Comp Endocrinol. 136: 270-5. PMID: 15028531
- 1Alpha,25-dihydroxyvitamin D3-mediated stimulation of steroid sulphatase activity in myeloid leukaemic cell lines requires VDRnuc-mediated activation of the RAS/RAF/ERK-MAP kinase signalling pathway. | Hughes, PJ. and Brown, G. 2006. J Cell Biochem. 98: 590-617. PMID: 16440327
- Protein kinase C beta and delta isoenzymes mediate cholesterol accumulation in PMA-activated macrophages. | Ma, HT., et al. 2006. Biochem Biophys Res Commun. 349: 214-20. PMID: 16930534
- Foreign body-type multinucleated giant cell formation requires protein kinase C beta, delta, and zeta. | McNally, AK., et al. 2008. Exp Mol Pathol. 84: 37-45. PMID: 18067888
- PKC-alpha controls MYD88-dependent TLR/IL-1R signaling and cytokine production in mouse and human dendritic cells. | Langlet, C., et al. 2010. Eur J Immunol. 40: 505-15. PMID: 19950169
- Berberine Reduces cAMP-Induced Chloride Secretion in T84 Human Colonic Carcinoma Cells through Inhibition of Basolateral KCNQ1 Channels. | Alzamora, R., et al. 2011. Front Physiol. 2: 33. PMID: 21747769
- Central role of PKCα in isoenzyme-selective regulation of cardiac transient outward current Ito and Kv4.3 channels. | Scholz, EP., et al. 2011. J Mol Cell Cardiol. 51: 722-9. PMID: 21803046
- The α1-adrenergic receptors in the amygdala regulate the induction of learned despair through protein kinase C-beta signaling. | Fujita, S., et al. 2021. Behav Pharmacol. 32: 73-85. PMID: 33164996
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HBDDE, 1 mg | sc-202174 | 1 mg | $210.00 | |||
HBDDE, 5 mg | sc-202174A | 5 mg | $715.00 |