HAUSP Antibody (C-2): sc-133204
- HAUSP Antibody (C-2) is a mouse monoclonal IgG1 κ, cited in 5 publications, provided at 200 µg/ml
- raised against amino acids 11-210 mapping near the N-terminus of HAUSP of human origin
- recommended for detection of HAUSP of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG1 BP-HRP is the preferred secondary detection reagent for HAUSP Antibody (C-2) for WB applications. This reagent is now offered in a bundle with HAUSP Antibody (C-2) (see ordering information below).
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HAUSP Antibody (C-2) is a mouse monoclonal IgG1 antibody that detects HAUSP (herpesvirus-associated ubiquitin-specific protease, USP7) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). HAUSP is a crucial ubiquitin-specific protease primarily localized in the nucleus, where HAUSP plays a significant role in regulating the stability of the tumor suppressor protein p53. By deubiquitinating p53, HAUSP prevents p53 degradation, thereby enhancing p53′s ability to induce cell cycle arrest and apoptosis in response to cellular stress or DNA damage. This function is particularly important in cancer contexts, as p53 is often mutated or inactivated in tumors, and HAUSP′s activity can influence cellular response to oncogenic signals. HAUSP′s interaction with ND10 nuclear structures further underscores HAUSP′s role in cellular stress responses and viral infections, as ND10 are involved in regulating various cellular processes, including interferon response and oncogenesis. Anti-HAUSP antibody (C-2) is an essential tool for researchers studying p53 regulation mechanisms and cellular pathways involved in tumorigenesis and viral pathogenesis.
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HAUSP Antibody (C-2) References:
- HAUSP/USP7 as an Epstein-Barr virus target. | Holowaty, MN. and Frappier, L. 2004. Biochem Soc Trans. 32: 731-2. PMID: 15494000
- HAUSP compartmentalization in chronic myeloid leukemia. | Morotti, A., et al. 2015. Eur J Haematol. 94: 318-21. PMID: 25082234
- HAUSP regulates c-MYC expression via de-ubiquitination of TRRAP. | Bhattacharya, S. and Ghosh, MK. 2015. Cell Oncol (Dordr). 38: 265-77. PMID: 25925205
- HAUSP-nucleolin interaction is regulated by p53-Mdm2 complex in response to DNA damage response. | Lim, KH., et al. 2015. Sci Rep. 5: 12793. PMID: 26238070
- Unleashing the Guardian: The Targetable BCR-ABL/HAUSP/PML/PTEN Network in Chronic Myeloid Leukemia. | Morotti, A., et al. 2017. Curr Drug Targets. 18: 389-395. PMID: 27291926
- USP7/HAUSP: A SUMO deubiquitinase at the heart of DNA replication. | Smits, VA. and Freire, R. 2016. Bioessays. 38: 863-8. PMID: 27374980
- Modulation of the p53/MDM2 interplay by HAUSP inhibitors. | Tavana, O. and Gu, W. 2017. J Mol Cell Biol. 9: 45-52. PMID: 27927749
- K63-polyubiquitinated HAUSP deubiquitinates HIF-1α and dictates H3K56 acetylation promoting hypoxia-induced tumour progression. | Wu, HT., et al. 2016. Nat Commun. 7: 13644. PMID: 27934968
- Targeting HAUSP in both p53 wildtype and p53-mutant tumors. | Tavana, O., et al. 2018. Cell Cycle. 17: 823-828. PMID: 29616860
- HAUSP Is a Key Epigenetic Regulator of the Chromatin Effector Proteins. | Abdullah, O. and Alhosin, M. 2021. Genes (Basel). 13: PMID: 35052383
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HAUSP Antibody (C-2) | sc-133204 | 200 µg/ml | $316.00 | |||
HAUSP Antibody (C-2): m-IgG1 BP-HRP Bundle | sc-542641 | 200 µg Ab; 20 µg BP | $354.00 |