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HATU is useful as a peptide coupling agent and a catalyst for selective acylation. It is also a reagent for reactions involving amide bond formations. HATU, a highly efficient coupling reagent, finds extensive use in solid and solution-phase peptide synthesis. In a comparative study, HATU demonstrated superior coupling yields and generated smaller enantiomers when compared to HBTU and TBTU. Although DMF is the typical solvent, other non-polar compounds are also employed. When in the presence of HOAt, HATU forms HOAt, leading to the creation of activated esters that display high sensitivity to amino acids. While a side reaction may produce guanidine by-products, the addition of HOBt helps mitigate this. Interestingly, although initially considered an urea-based salt, x-ray analysis revealed HATU′s structure to be that of a guanidinium oxide.
Ordering Information
Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HATU, 5 g | sc-211580 | 5 g | $52.00 | |||
HATU, 25 g | sc-211580A | 25 g | $190.00 |