Date published: 2026-10-21

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Harzianum A (CAS 156250-74-7)

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Alternate Names:
Trichothec-9-en-4-ol
Application:
Harzianum A is an anticancer compound that is cytotoxic to human cancer cell lines
CAS Number:
156250-74-7
Purity:
≥95%
Molecular Weight:
400.46
Molecular Formula:
C23H28O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Harzianum A is a secondary metabolite with a focus on its role in the biological control of plant pathogens. Its antifungal properties are of particular interest in agricultural research, where Harzianum A is studied for its effects on crop protection and yield improvement. The compound has been observed to inhibit the growth of various plant-pathogenic fungi, a mechanism that is valuable in the development of environmentally friendly agricultural practices. In addition, Harzianum A has been utilized in studies of microbial interactions in soil ecosystems, providing insight into the competition and survival strategies of microorganisms. Research on Harzianum A also extends to its influence on plant immune responses, where it is used to study the induction of systemic resistance in plants against a broad spectrum of diseases.


Harzianum A (CAS 156250-74-7) References

  1. A new Hypocrea strain producing harzianum A cytotoxic to tumour cell lines.  |  Lee, HB., et al. 2005. Lett Appl Microbiol. 40: 497-503. PMID: 15892749
  2. Trichothecene production by Trichoderma brevicompactum.  |  Nielsen, KF., et al. 2005. J Agric Food Chem. 53: 8190-6. PMID: 16218663
  3. Production of trichodiene by Trichoderma harzianum alters the perception of this biocontrol strain by plants and antagonized fungi.  |  Malmierca, MG., et al. 2015. Environ Microbiol. 17: 2628-46. PMID: 24813508
  4. Novel aspinolide production by Trichoderma arundinaceum with a potential role in Botrytis cinerea antagonistic activity and plant defence priming.  |  Malmierca, MG., et al. 2015. Environ Microbiol. 17: 1103-18. PMID: 24889745
  5. Relevance of the deletion of the Tatri4 gene in the secondary metabolome of Trichoderma arundinaceum.  |  Izquierdo-Bueno, I., et al. 2018. Org Biomol Chem. 16: 2955-2965. PMID: 29623313
  6. Effect of deletion of a trichothecene toxin regulatory gene on the secondary metabolism transcriptome of the saprotrophic fungus Trichoderma arundinaceum.  |  Lindo, L., et al. 2018. Fungal Genet Biol. 119: 29-46. PMID: 30121242
  7. Requirement of Two Acyltransferases for 4- O-Acylation during Biosynthesis of Harzianum A, an Antifungal Trichothecene Produced by Trichoderma arundinaceum.  |  Lindo, L., et al. 2019. J Agric Food Chem. 67: 723-734. PMID: 30558420
  8. A cytochrome P450 monooxygenase gene required for biosynthesis of the trichothecene toxin harzianum A in Trichoderma.  |  Cardoza, RE., et al. 2019. Appl Microbiol Biotechnol. 103: 8087-8103. PMID: 31384992
  9. Herbicidal efficacy of harzianums produced by the biofertilizer fungus, Trichoderma brevicompactum.  |  Yin, M., et al. 2020. AMB Express. 10: 118. PMID: 32613360
  10. Trichothecenes in food and feed: Occurrence, impact on human health and their detection and management strategies.  |  Mahato, DK., et al. 2022. Toxicon. 208: 62-77. PMID: 35104534
  11. Identification of polyketide synthase genes required for aspinolide biosynthesis in Trichoderma arundinaceum.  |  Cardoza, RE., et al. 2022. Appl Microbiol Biotechnol. 106: 7153-7171. PMID: 36166052
  12. Effects of trichothecene production by Trichoderma arundinaceum isolates from bean-field soils on the defense response, growth and development of bean plants (Phaseolus vulgaris).  |  Cardoza, RE., et al. 2022. Front Plant Sci. 13: 1005906. PMID: 36452093

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Harzianum A, 250 µg

sc-391077
250 µg
$82.00

Harzianum A, 1 mg

sc-391077A
1 mg
$224.00