Molecular structure of Harmine, CAS Number: 442-51-3
Harmine (CAS 442-51-3)
See product citations (2)
Application:
Harmine is an alkaloid of the β-carboline family that regulates PPARγ expression.
CAS Number:
442-51-3
Purity:
≥97%
Molecular Weight:
212.25
Molecular Formula:
C13H12N2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Harmine is an alkaloid of the beta-carboline family that regulates PPARgamma expression. Harmine inhibits the Wnt signaling pathway in a cell-specific manner and down-regulates inflammatory gene expression (TNF-alpha, IL-1beta, iNOS). It reversibly inhibits MAO-A (monoamine oxidase A) but has no effect on MAO-B. Additionally, Harmine is an inhibitor of Dyrk1A, Dyrk2 and Dyrk3.
Harmine (CAS 442-51-3) References
- The mode of action of thiazolidinediones. | Hauner, H. 2002. Diabetes Metab Res Rev. 18 Suppl 2: S10-5. PMID: 11921433
- INTERRELATIONSHIPS BETWEEN AMPHETAMINE AND HARMALA ALKALOIDS. | SCHMITT, H. and SCHMITT, H. 1964. Nature. 203: 877-8. PMID: 14204082
- Antitumor and neurotoxic effects of novel harmine derivatives and structure-activity relationship analysis. | Chen, Q., et al. 2005. Int J Cancer. 114: 675-82. PMID: 15609303
- The chemotherapy of derivatives of harmine and harmaline. I. | Coulthard, CE., et al. 1933. Biochem J. 27: 727-39. PMID: 16745151
- The chemotherapy of derivatives of harmine and harmaline. II. | Coulthard, CE. 1934. Biochem J. 28: 264-7. PMID: 16745362
- The small molecule harmine is an antidiabetic cell-type-specific regulator of PPARgamma expression. | Waki, H., et al. 2007. Cell Metab. 5: 357-70. PMID: 17488638
- Novel harmine derivatives for tumor targeted therapy. | Li, S., et al. 2015. Oncotarget. 6: 8988-9001. PMID: 25940702
- Effect of Harmine and Its Derivatives Against Echinococcus granulosus and Comparison of DNA Damage Targets. | Gong, Y., et al. 2020. J Biomed Nanotechnol. 16: 827-841. PMID: 33187579
- Central inhibition prevents the in vivo acute toxicity of harmine in mice. | Lv, Y., et al. 2021. J Toxicol Sci. 46: 289-301. PMID: 34078836
- Harmine impairs memory performance of treated rats and nontreated cagemates. | Libânio, TC., et al. 2022. Exp Clin Psychopharmacol. 30: 751-759. PMID: 34735205
- Harmine-based dual inhibitors targeting histone deacetylase (HDAC) and DNA as a promising strategy for cancer therapy. | Lu, D., et al. 2022. Bioorg Chem. 120: 105604. PMID: 35051708
- Evaluation of the Effects of Harmine on β-cell Function and Proliferation in Standardized Human Islets Using 3D High-Content Confocal Imaging and Automated Analysis. | Title, AC., et al. 2022. Front Endocrinol (Lausanne). 13: 854094. PMID: 35860702
- Harmine, an inhibitor of the type III secretion system of Salmonella enterica serovar Typhimurium. | Shi, Y., et al. 2022. Front Cell Infect Microbiol. 12: 967149. PMID: 36176578
- Effect of moclobemide on rat brain monoamine oxidase A and B: comparison with harmaline and clorgyline. | Gerardy, J. 1994. Prog Neuropsychopharmacol Biol Psychiatry. 18: 793-802. PMID: 7938567
- Hypothermic effect of harmala alkaloid in rats: involvement of serotonergic mechanism. | Abdel-Fattah, AF., et al. 1995. Pharmacol Biochem Behav. 52: 421-6. PMID: 8577810
Inhibitor of:
4930521A18Rik, 9330101J02Rik, ADCK4, B930011P16Rik, C12orf50_1700017N19Rik, C2orf37, C430003P19Rik, CKIP-1, CLK1, CLK2, COASTER, CstF-50, DBX2, DDX34, DNAH9, DNAHC7A, DOC2BL, Dyrk1A, Dyrk1B, Dyrk2, Dyrk3, FAM111B, GAK, GPATCH1, IFT52, IGHMBP2, INMT, KIAA1257, KRTAP10-1, LCA5, LRCH4, MAO-A, NF90, NUDE1, Odf2L, RTEL1, SFRS14, Sm N, SPEN, SR, SRPK3, TAF5L, Tctex2 β, TSGA10IP, TTBK1, TTBK2, and UBXD3.Activator of:
α3e Tubulin, 2810403A07Rik, Clik1, CLK3, CLK4, CSAP, DUX5, Dyrk2, Dyrk4, GPATCH4, KIAA1737, Pin1l, PRPF40B, SRp30c, and TSHZ3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Harmine, 250 mg | sc-202644 | 250 mg | $52.00 | |||
Harmine, 500 mg | sc-202644A | 500 mg | $102.00 | |||
Harmine, 1 g | sc-202644B | 1 g | $124.00 | |||
Harmine, 10 g | sc-202644C | 10 g | $540.00 | |||
Harmine, 50 g | sc-202644D | 50 g | $1438.00 | |||
Harmine, 100 g | sc-202644E | 100 g | $2560.00 | |||
Harmine, 500 g | sc-202644F | 500 g | $11230.00 |