Haptoglobin α Antibody (E-9): sc-374208

Haptoglobin α Antibody (E-9) is a mouse monoclonal IgG2b antibody that detects Haptoglobin α in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Haptoglobin α plays a crucial role in the immune response by binding free hemoglobin released from erythrocytes, which not only inhibits oxidative activity but also sequesters iron, thereby preventing iron-utilizing bacteria from exploiting hemolysis. This protective mechanism is particularly important during inflammation, as elevated Haptoglobin levels can indicate an acute phase response, helping to mitigate tissue damage and infection. Haptoglobin α protein is composed of two α and two β chains linked by disulfide bridges, and this structure is essential for function and interaction with hemoglobin. In humans, Haptoglobin exists in two allelic forms, Hp1 and Hp2, with three known phenotypes that have been associated with various health conditions, including diabetes and cardiovascular diseases, as well as susceptibility to neurodegenerative disorders like Parkinson′s disease. The ability to accurately measure Haptoglobin levels is vital for diagnosing hemolytic anemia, making anti-Haptoglobin α antibody (E-9) an invaluable tool for researchers and clinicians studying these critical pathways in human health.

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Haptoglobin α Antibody (E-9) References:

1. Haptoglobin-alpha subunit as potential serum biomarker in ovarian cancer: identification and characterization using proteomic profiling and mass spectrometry.  |  Ye, B., et al. 2003. Clin Cancer Res. 9: 2904-11. PMID: 12912935
2. Primary structure details of haptoglobin alpha chain proteins from human plasma samples are resolved by matrix-assisted laser desorption/ionization quadrupole ion trap time-of-flight multiple-stage tandem mass spectrometry sequencing.  |  Koy, C., et al. 2004. Eur J Mass Spectrom (Chichester). 10: 393-9. PMID: 15187298
3. Mass spectrometric protein structure characterization reveals cause of migration differences of haptoglobin alpha chains in two-dimensional gel electrophoresis.  |  Mikkat, S., et al. 2004. Proteomics. 4: 3921-32. PMID: 15378693
4. Differentially expressed serum haptoglobin alpha chain isoforms with potential application for diagnosis of head and neck cancer.  |  Chen, CB., et al. 2008. Clin Chim Acta. 398: 48-52. PMID: 18727923
5. Presence of free haptoglobin alpha 1S-subunit in acute porcine reproductive and respiratory syndrome virus infection.  |  Gnanandarajah, JS., et al. 2008. J Gen Virol. 89: 2746-2753. PMID: 18931071
6. Serum proteome of patients with systemic sclerosis: molecular analysis of expression and prevalence of haptoglobin alpha chain isoforms.  |  Guerranti, R., et al. 2010. Int J Immunopathol Pharmacol. 23: 901-9. PMID: 20943062
7. Haptoglobin, alpha-thalassaemia and glucose-6-phosphate dehydrogenase polymorphisms and risk of abnormal transcranial Doppler among patients with sickle cell anaemia in Tanzania.  |  Cox, SE., et al. 2014. Br J Haematol. 165: 699-706. PMID: 24666344
8. Noninvasive embryo viability assessment by quantitation of human haptoglobin alpha-1 fragment in the in vitro fertilization culture medium: an additional tool to increase success rate.  |  Montskó, G., et al. 2015. Fertil Steril. 103: 687-93. PMID: 25577461
9. Localization of the haptoglobin alpha and beta genes (HPA and HPB) to human chromosome 16q22 by in situ hybridization.  |  McGill, JR., et al. 1984. Cytogenet Cell Genet. 38: 155-7. PMID: 6547898
10. Cancer cells release a covalent complex containing disulfide-linked domains from urinary plasminogen activator, neural cell adhesion molecule, and haptoglobin alpha and beta chains.  |  Harvey, SR., et al. 1997. Arch Biochem Biophys. 345: 289-98. PMID: 9308901

The preferred Haptoglobin α antibody is Haptoglobin α Antibody (B-2): sc-365396.