Molecular structure of Haloperidol hydrochloride, CAS Number: 1511-16-6
Haloperidol hydrochloride (CAS 1511-16-6)
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Application:
Haloperidol hydrochloride is an inhibitor of D2DR, NMDA, and NOS1
CAS Number:
1511-16-6
Purity:
≥99%
Molecular Weight:
412.33
Molecular Formula:
C21H23ClFNO2•HCl
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Haloperidol hydrochloride is a dopamine inhibitor selective for D2DR (Ki values are 1.2, ~ 7, 2.3, ~ 80 and ~ 100 nM for D2DR, D3DR, D4DR, D1DR and D5DR receptors respectively). Haloperidol is a subtype-selective NMDA inhibitor and also acts as a non-competitive inhibitor of NOS1 (nNOS) activity (Ki = 31 muM). Haloperidol hydrochloride is an inhibitor of D2DR, D3DR and D4DR.
Haloperidol hydrochloride (CAS 1511-16-6) References
- Differential effects of acute administration of haloperidol and clozapine on ethanol-induced ascorbic acid release in rat striatum. | Liu, W., et al. 2000. Eur J Pharmacol. 398: 333-9. PMID: 10862822
- Investigation of solubility and dissolution of a free base and two different salt forms as a function of pH. | Li, S., et al. 2005. Pharm Res. 22: 628-35. PMID: 15846471
- Stability of tramadol and haloperidol for continuous subcutaneous infusion at home. | Negro, S., et al. 2005. J Pain Symptom Manage. 30: 192-9. PMID: 16125035
- Effect of chloride ion on dissolution of different salt forms of haloperidol, a model basic drug. | Li, S., et al. 2005. J Pharm Sci. 94: 2224-31. PMID: 16136556
- Sila-haloperidol, a silicon analogue of the dopamine (D2) receptor antagonist haloperidol: synthesis, pharmacological properties, and metabolic fate. | Tacke, R., et al. 2008. ChemMedChem. 3: 152-64. PMID: 18022977
- Supersolubilization and amorphization of a model basic drug, haloperidol, by interaction with weak acids. | Singh, S., et al. 2013. Pharm Res. 30: 1561-73. PMID: 23430485
- Evaluation of the in vitro cytogenotoxicity profile of antipsychotic drug haloperidol using human peripheral blood lymphocytes. | Gajski, G., et al. 2014. Environ Toxicol Pharmacol. 38: 316-24. PMID: 25036041
- Invariom based electron density studies on the C/Si analogues haloperidol/sila-haloperidol and venlafaxine/sila-venlafaxine. | Luger, P., et al. 2015. Org Biomol Chem. 13: 9093-106. PMID: 26222713
- Visualization of Protonation/Deprotonation of Active Pharmaceutical Ingredient in Solid State by Vapor Phase Amine-Selective Alkyne Tagging and Raman Imaging. | Moriyama, K., et al. 2017. J Pharm Sci. 106: 1778-1785. PMID: 28322938
- Beta-Alanine and Tris-(hydroxyl methyl) Aminomethane as Peak Modifiers in the Development of RP-HPLC Methods Using Aceclofenac and Haloperidol Hydrochloride as Exemplar Drugs. | Peraman, R., et al. 2021. J Chromatogr Sci. 59: 899-908. PMID: 33618356
- Effects of haloperidol on morphine-induced antinociception morphine tolerance and withdrawal in hyperprolactinaemic rats. | Drago, F., et al. 1985. Neuropharmacology. 24: 1027-31. PMID: 4080101
- Noradrenergic and dopaminergic interactions in escape behavior: analysis of uncontrollable stress effects. | Anisman, H., et al. 1981. Psychopharmacology (Berl). 74: 263-8. PMID: 6791235
- Effect of fenfluramine and norfenfluramine stereoisomers on stimulant effects of d-amphetamine and apomorphine in the rat. | Bendotti, C., et al. 1980. Pharmacol Res Commun. 12: 567-74. PMID: 7190710
Inhibitor of:
D2DR, D3DR, D4DR, D5DR, NMDA, and NOS1.Substrate of:
Sigma Receptor.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Haloperidol hydrochloride, 100 mg | sc-203593 | 100 mg | $72.00 |