Halofuginone Hydrochloride is the hydrochloride salt preparation of Halofuginone, a halogenated analog of the antimalarial alkaloid febrifugine. The bromide and chloride substitutions of Halofuginone replace the metabolically vulnerable aromatic protons of febrifugine. Halofuginone is described to produce antiprotozoal, antiangiogenic, and antiproliferative effects, and is also reported to inhibit the biosynthesis of type 1 collagen.
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Stable for up to 1 year after receipt when stored at -20°C. Stock solutions should be aliquoted and stored at -20°C for up to 1 month. Packaged under inert gas, protect from light.
Soluble in DMSO, and methanol.
Store at -20° C
237-242° C (dec.)
n20D 1.71 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Rated 5 out of
ChenChen, GQ. et al. (PubMed 26160839) discovered that Halofuginone, a halogenated analog of the antimalarial alkaloid febrifugine, treatment inhibits colorectal cancer growth both in vitro and in vivo through regulation of Akt/mTORC1 signaling pathway. -SCBT Publication Review
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