Halofuginone Hydrochloride CAS: 1217623-74-9
MF: C16H17BrClN3O3•HCl
MW: 451.14
A halogenated derivative of febrigugine.

Halofuginone Hydrochloride (CAS 1217623-74-9)

Halofuginone Hydrochloride | CAS 1217623-74-9 is rated 5.0 out of 5 by 1.
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Alternate Names: rel-7-Bromo-6-chloro-3-[3-[(2R,3S)-3-hydroxy-2-piperidinyl]-2-oxopropyl]-4(3H)-quinazolinone Hydrochloride; 7-Bromo-6-chlorofebrifugine Hydrochloride; HAL
Application: Halofuginone Hydrochloride is a halogenated derivative of febrigugine
CAS Number: 1217623-74-9
Purity: ≥95%
Molecular Weight: 451.14
Molecular Formula: C16H17BrClN3O3•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Halofuginone Hydrochloride is the hydrochloride salt preparation of Halofuginone, a halogenated analog of the antimalarial alkaloid febrifugine. The bromide and chloride substitutions of Halofuginone replace the metabolically vulnerable aromatic protons of febrifugine. Halofuginone is described to produce antiprotozoal, antiangiogenic, and antiproliferative effects, and is also reported to inhibit the biosynthesis of type 1 collagen.


References

1. Yee, K.O., et al. 2006. Cancer Biol. Ther. 5: 218-224. PMID: 16418571

2. de Jonge, M.J., et al. 2006. Eur. J. Cancer. 42: 1768-1774. PMID: 16815702

3. McLaughlin, N.P. and Evans, P. 2010. J. Org. Chem. 75: 518-521. PMID: 20000346

Usage :
Stable for up to 1 year after receipt when stored at -20°C. Stock solutions should be aliquoted and stored at -20°C for up to 1 month. Packaged under inert gas, protect from light.
Physical State :
Solid
Solubility :
Soluble in DMSO, and methanol.
Storage :
Store at -20° C
Melting Point :
237-242° C (dec.)
Refractive Index :
n20D 1.71 (Predicted)
pK Values :
pKb: 8.73
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
VA2397066
PubChem CID :
71317187
MDL Number :
MFCD09839202
SMILES :
Cl.OC1CCCN[[email protected]]1CC(=O)CN1C=NC2=CC(Br)=C(Cl)C=C2C1=O

Download SDS (MSDS)

Certificate of Analysis

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Halofuginone Hydrochloride (CAS 1217623-74-9)  Product Citations

See how others have used Halofuginone Hydrochloride (CAS 1217623-74-9). Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 27211859  O'Connell, DJ. et al. 2016. Cell Syst. 2: 323-334.

Citations 1 to 1 of 1 total

What are the shipping conditions?

Asked by: SCchem16
Thank you for your question. This chemical, Halofuginone Hydrochloride (CAS 1217623-74-9), will ship ambient domestically and internationally.
Answered by: Chemical Support 2
Date published: 2017-02-28
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Rated 5 out of 5 by from Chen Chen, GQ. et al. (PubMed 26160839) discovered that Halofuginone, a halogenated analog of the antimalarial alkaloid febrifugine, treatment inhibits colorectal cancer growth both in vitro and in vivo through regulation of Akt/mTORC1 signaling pathway. -SCBT Publication Review
Date published: 2015-02-22
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