Molecular structure of Halofuginone Hydrobromide
Halofuginone Hydrobromide (CAS 64924-67-0)
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Alternate Names:
rel-7-Bromo-6-chloro-3-[3-[(2R,3S)-3-hydroxy-2-piperidinyl]-2-oxopropyl]-4(3H)-quinazolinone Hydrobromide; trans-(±)-7-Bromo-6-chloro-3-[3-(3-hydroxy-2- piperidinyl)-2-oxopropyl]-4(3H)-quinazolinone Monohydrobromide
CAS Number:
64924-67-0
Molecular Weight:
495.59
Molecular Formula:
C16H17BrClN3O3•HBr
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Halofuginone Hydrobromide is the hydrobromide form of halofuginone, an anticoccidial compound that originates from the plant Dichroa febrifuga. It possesses antifibrotic properties and potential antineoplastic effects. Halofuginone specifically hinders the expression of collagen type I and matrix metalloproteinase 2 (MMP-2) genes, potentially leading to the suppression of processes like angiogenesis, the development of tumor stromal cells, and the growth of tumors. These actions are attributed to halofuginone′s ability to inhibit the promoters responsible for collagen type I and MMP-2. Both collagen type I and MMP-2 are significant factors in fibro-proliferative diseases.
Halofuginone Hydrobromide (CAS 64924-67-0) References
- Field study of the efficacy of halofuginone and decoquinate in the treatment of cryptosporidiosis in veal calves. | Lallemand, M., et al. 2006. Vet Rec. 159: 672-6. PMID: 17099176
- Potential therapeutical effects of topical halofuginone hydrobromide in keloid management. | Lista, S. and Emanuele, E. 2007. Med Hypotheses. 69: 707. PMID: 17331662
- A Novel Synthesis of the Efficient Anti-Coccidial Drug Halofuginone Hydrobromide. | Zhang, J., et al. 2017. Molecules. 22: PMID: 28665346
- Safety and efficacy of STENOROL® (halofuginone hydrobromide) as a feed additive for chickens for fattening and turkeys. | , ., et al. 2020. EFSA J. 18: e06169. PMID: 33209147
- Encapsulating Halofuginone Hydrobromide in TPGS Polymeric Micelles Enhances Efficacy Against Triple-Negative Breast Cancer Cells. | Zuo, R., et al. 2021. Int J Nanomedicine. 16: 1587-1600. PMID: 33664573
- Efficacy of halofuginone as a coccidiostat for turkeys. | Waibel, PE., et al. 1987. Poult Sci. 66: 1629-34. PMID: 3432190
- Safety of a feed additive consisting of halofuginone hydrobromide (STENOROL®) for chickens for fattening and turkeys (Huvepharma N.V.). | , ., et al. 2022. EFSA J. 20: e07716. PMID: 36545572
- Nano-encapsulation of halofuginone hydrobromide enhances anticoccidial activity against Eimeria tenella in chickens. | Lin, M., et al. 2023. Biomater Sci. 11: 1725-1738. PMID: 36648120
- Safety and efficacy of a feed additive consisting of halofuginone hydrobromide (STENOROL®) for chickens for fattening and turkeys for fattening/reared for breeding (Huvepharma N.V.). | , ., et al. 2023. EFSA J. 21: e07978. PMID: 37089180
- Determination of halofuginone hydrobromide in medicated animal feeds. | . 1983. Analyst. 108: 1252-6. PMID: 6650842
- Liquid chromatographic determination of the anticoccidial drug halofuginone hydrobromide in eggs. | Holland, DC., et al. 1995. J AOAC Int. 78: 37-40. PMID: 7703725
- Halofuginone, a specific collagen type I inhibitor, reduces anastomotic intimal hyperplasia. | Choi, ET., et al. 1995. Arch Surg. 130: 257-61. PMID: 7887792
- Therapeutic efficacy of halofuginone and spiramycin treatment against Cryptosporidium serpentis (Apicomplexa: Cryptosporidiidae) infections in captive snakes. | Graczyk, TK., et al. 1996. Parasitol Res. 82: 143-8. PMID: 8825209
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Halofuginone Hydrobromide, 10 mg | sc-490904 | 10 mg | $341.00 |