Date published: 2025-9-26

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Halobetasol Propionate (CAS 66852-54-8)

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Alternate Names:
(6α,11β,16β)-21-Chloro-6,9-difluoro-11-hydroxy-16-methyl-17-(1-oxopropoxy)pregna-1,4-diene-3,20-dione; Miracorten; Ulobetasol propionate
Application:
Halobetasol Propionate is an anti-inflammatory and a dermatologic agent
CAS Number:
66852-54-8
Molecular Weight:
484.96
Molecular Formula:
C25H31ClF2O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Halobetasol Propionate is a compound explored extensively in the field of dermatological research. Its high potency and anti-inflammatory properties make it a focal point for studies on skin inflammation and the mechanisms by which inflammation can be modulated at the cellular level. Researchers are interested in the compound′s ability to inhibit the production of cytokines and chemokines, which are critical mediators in the inflammatory process. In addition, Halobetasol Propionate is used to study the proliferation and differentiation of keratinocytes, cells that make up a large part of the epidermal layer in the skin. Its effects on various signaling pathways, such as those involving mitogen-activated protein kinases (MAPKs), are also a subject of investigation, as these pathways play a role in cellular responses to external stressors.


Halobetasol Propionate (CAS 66852-54-8) References

  1. Topical halobetasol propionate in the treatment of plaque psoriasis: a review.  |  Rivera, AM. and Hsu, S. 2005. Am J Clin Dermatol. 6: 311-6. PMID: 16252930
  2. Dermatopharmacologic investigations of halobetasol propionate in comparison with clobetasol 17-propionate.  |  Yawalkar, S., et al. 1991. J Am Acad Dermatol. 25: 1137-44. PMID: 1757603
  3. Safety and Efficacy of a Halobetasol 0.01%/Tazarotene 0.045% Fixed Combination Lotion in the Treatment of Moderate-to-severe Plaque Psoriasis: A Comparison with Halobetasol Propionate 0.05% Cream.  |  Bhatia, ND., et al. 2018. J Clin Aesthet Dermatol. 11: 15-19. PMID: 30588269
  4. A novel halobetasol propionate 0.01%/tazarotene 0.045% fixed combination treatment for psoriasis.  |  Radonjic, A. and Evans, EL. 2019. Dermatol Ther. 32: e12979. PMID: 31155813
  5. Treating Psoriasis With Halobetasol Propionate and Tazarotene Combination: A Review of Phase II and III Clinical Trials.  |  Ramachandran, V., et al. 2020. Ann Pharmacother. 54: 872-878. PMID: 32126800
  6. Halobetasol propionate for the management of psoriasis.  |  Bagel, J., et al. 2020. Cutis. 105: 92-96;E4. PMID: 32186526
  7. Fixed-Combination Halobetasol Propionate and Tazarotene in the Treatment of Psoriasis: Narrative Review of Mechanisms of Action and Therapeutic Benefits.  |  Lebwohl, MG., et al. 2021. Dermatol Ther (Heidelb). 11: 1157-1174. PMID: 34106439
  8. Halobetasol propionate lotion 0.05% in patients 12 to 16 years 11 months of age with plaque psoriasis: Results of an open-label study evaluating adrenal suppression potential.  |  Laquer, V., et al. 2022. JAAD Int. 6: 13-19. PMID: 34870246
  9. Fixed Combination Halobetasol Propionate and Tazarotene Lotion for Plaque Psoriasis.  |  Guenther, L., et al. 2021. Skin Therapy Lett. 26: 1-3. PMID: 34871475
  10. Halobetasol Propionate 0.01% Lotion for Plaque Psoriasis and Corticosteroid-Responsive Dermatoses.  |  Abduelmula, A., et al. 2022. Skin Therapy Lett. 27: 1-4. PMID: 35533304
  11. Adjunctive Use of Halobetasol Propionate-Tazarotene in Biologic-Experienced Patients With Psoriasis.  |  Bagel, J., et al. 2022. Cutis. 109: 103-109. PMID: 35659807
  12. A critical review of halobetasol propionate foam (0.05%) as a treatment option for adolescent plaque psoriasis.  |  Chung, M., et al. 2022. Expert Rev Clin Immunol. 18: 997-1003. PMID: 35930002
  13. Challenges in Psoriatic Disease Addressed by Fixed-Combination Halobetasol Propionate 0.01% and Tazarotene 0.045% Lotion.  |  Kircik, L., et al. 2023. J Clin Aesthet Dermatol. 16: 21-26. PMID: 36950046

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Halobetasol Propionate, 10 mg

sc-211578
10 mg
$282.00