HA-1004 Dihydrochloride (CAS 91742-10-8)
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HA-1004 dihydrochloride is frequently used in biochemical research due to its properties as a protein kinase inhibitor, specifically targeting cyclic nucleotide-dependent protein kinases. This compound is essential in studies aimed at deciphering the roles of these kinases in cellular signaling pathways. Research employing HA-1004 dihydrochloride often focuses on its effects on intracellular communication and regulation, particularly in the context of cell growth and differentiation. Additionally, HA-1004 dihydrochloride is utilized in research investigating the mechanisms of learning and memory, as protein kinases play a pivotal role in neuronal plasticity and response. This compound also helps in understanding the pathological states where protein kinase activity is disrupted, providing insights into potential avenues for intervention in disease processes.
HA-1004 Dihydrochloride (CAS 91742-10-8) References
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- Nur77 nuclear import and its NBRE-binding activity in thymic lymphoma cells are regulated by different mechanisms sensitive to FK506 or HA1004. | Kochel, I., et al. 2005. Biochem Biophys Res Commun. 334: 1102-6. PMID: 16051191
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- Thiol oxidation causes pulmonary vasodilation by activating K+ channels and inhibiting store-operated Ca2+ channels. | Schach, C., et al. 2007. Am J Physiol Lung Cell Mol Physiol. 292: L685-98. PMID: 17098807
- The PKs PKA and ERK 1/2 are involved in phosphorylation of TH at Serine 40 and 31 during morphine withdrawal in rat hearts. | Almela, P., et al. 2008. Br J Pharmacol. 155: 73-83. PMID: 18536752
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- Lidocaine-induced apoptosis of gingival fibroblasts: participation of cAMP and PKC activity. | Villarruel, EQ., et al. 2011. Cell Biol Int. 35: 783-8. PMID: 21047305
- Relaxation of vascular smooth muscle by HA-1004, an inhibitor of cyclic nucleotide-dependent protein kinase. | Ishikawa, T., et al. 1985. J Pharmacol Exp Ther. 235: 495-9. PMID: 2997436
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HA-1004 Dihydrochloride, 10 mg | sc-200537 | 10 mg | $86.00 | |||
HA-1004 Dihydrochloride, 25 mg | sc-200537A | 25 mg | $265.00 |