H3-K9-HMTase Antibody (LD87): sc-130475

H3-K9-HMTase Antibody (LD87) is a mouse monoclonal IgG2a kappa light chain antibody that detects H3-K9-HMTase protein of human origin by western blotting (WB) and immunoprecipitation (IP). Anti-H3-K9-HMTase antibody (LD87) is available as non-conjugated format. H3-K9-HMTase, also known as histone-lysine N-methyltransferase SETDB2, is a crucial 719 amino acid protein encoded by the human gene SETDB2, which plays a significant role in epigenetic regulation. H3-K9-HMTase (LD87) antibody targets a protein primarily located in the nucleus that methylates lysine 9 on histone H3, a modification pivotal for gene silencing and chromatin structure. This modification influences recruitment of various effector proteins that further regulate gene expression, impacting cellular processes such as differentiation and development. H3-K9-HMTase shows ubiquitous expression, with highest levels in heart, testis, and ovary, highlighting its importance in both reproductive and cardiac functions. Understanding H3-K9-HMTase′s role in these tissues provides insights into developmental biology and potential implications in diseases related to epigenetic dysregulation.

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H3-K9-HMTase Antibody (LD87) References:

1. Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9.  |  Tachibana, M., et al. 2005. Genes Dev. 19: 815-26. PMID: 15774718
2. Functional analysis of the N- and C-terminus of mammalian G9a histone H3 methyltransferase.  |  Estève, PO., et al. 2005. Nucleic Acids Res. 33: 3211-23. PMID: 15939934
3. H3 lysine 9 methylation is maintained on a transcribed inverted repeat by combined action of SUVH6 and SUVH4 methyltransferases.  |  Ebbs, ML., et al. 2005. Mol Cell Biol. 25: 10507-15. PMID: 16287862
4. Nuclear RanGAP is required for the heterochromatin assembly and is reciprocally regulated by histone H3 and Clr4 histone methyltransferase in Schizosaccharomyces pombe.  |  Nishijima, H., et al. 2006. Mol Biol Cell. 17: 2524-36. PMID: 16540522
5. E2F activation of S phase promoters via association with HCF-1 and the MLL family of histone H3K4 methyltransferases.  |  Tyagi, S., et al. 2007. Mol Cell. 27: 107-19. PMID: 17612494
6. Epigenetic regulation of the Drosophila chromosome 4 by the histone H3K9 methyltransferase dSETDB1.  |  Tzeng, TY., et al. 2007. Proc Natl Acad Sci U S A. 104: 12691-6. PMID: 17652514
7. Implications of a histone code mimic in epigenetic signaling.  |  Henkels, CH. and Khorasanizadeh, S. 2007. Mol Cell. 27: 521-2. PMID: 17707224

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-H3-K9-HMTase Antibody (LD87) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-H3-K9-HMTase Antibody (LD87) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

H3-K9-HMTase Antibody (LD87) Specifications

Alternate Product Name: H3-K9-HMTase

Product Clone Name: LD87

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 620-720

Epitope Target: H3-K9-HMTase

Epitope Species: human

Product Reactivity/Detection: H3-K9-HMTase

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 50 µg IgG_2a kappa light chain in 0.5 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for H3-K9-HMTase Antibody (LD87): N/A