H2-I/Eκ Antibody (17-3-3): sc-52547

H2-I/Eκ Antibody (17-3-3) is a mouse monoclonal IgG2a antibody that detects H2-I/E kappa protein of mouse origin by flow cytometry (FCM). Anti-H2-I/E kappa antibody (17-3-3) is available in both non-conjugated and various conjugated forms, including phycoerythrin (PE), providing flexibility for different experimental needs. H2-I/E kappa protein plays a crucial role in the immune system as a component of the major histocompatibility complex (MHC) class II molecules, which are essential for the adaptive immune response. MHC class II molecules are responsible for presenting processed foreign antigens to CD4+ T helper cells, thereby initiating a cascade of immune responses. Proper functioning of MHC class II molecules is vital for T lymphocyte activation, which orchestrates immune responses against pathogens. MHC class II molecules consist of an alpha and beta chain forming a heterodimer, allowing for diverse peptide antigen binding and enhancing immune system recognition of various threats. Understanding H2-I/E kappa′s role in antigen presentation is important for developing targeted immunotherapies and vaccines, making H2-I/E kappa monoclonal antibody (17-3-3) a valuable tool for researchers studying immune responses in mouse models.

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H2-I/Eκ Antibody (17-3-3) References:

1. Dendritic cells permit identification of genes encoding MHC class II-restricted epitopes of transplantation antigens.  |  Scott, D., et al. 2000. Immunity. 12: 711-20. PMID: 10894170
2. Inhibition of autoimmune diabetes in nonobese diabetic mice by transgenic restoration of H2-E MHC class II expression: additive, but unequal, involvement of multiple APC subtypes.  |  Johnson, EA., et al. 2001. J Immunol. 167: 2404-10. PMID: 11490031
3. A humanized model of experimental autoimmune uveitis in HLA class II transgenic mice.  |  Pennesi, G., et al. 2003. J Clin Invest. 111: 1171-80. PMID: 12697736
4. Structure function analysis of the H-2 Abp gene.  |  Harton, JA., et al. 1991. Immunogenetics. 34: 358-65. PMID: 1748486
5. Hybridoma cell lines secreting monoclonal antibodies to mouse H-2 and Ia antigens.  |  Ozato, K., et al. 1980. J Immunol. 124: 533-40. PMID: 7188699
6. Studies on the interdependence of gp39 and B7 expression and function during antigen-specific immune responses.  |  Roy, M., et al. 1995. Eur J Immunol. 25: 596-603. PMID: 7533092
7. Non-coordinate synthesis of MHC class II proteins and invariant chains by epidermal Langerhans cells derived from short-term in vitro culture.  |  Neiss, U. and Reske, K. 1994. Int Immunol. 6: 61-71. PMID: 8148327
8. Differential expression of CLIP:MHC class II and conventional endogenous peptide:MHC class II complexes by thymic epithelial cells and peripheral antigen-presenting cells.  |  Farr, A., et al. 1996. Eur J Immunol. 26: 3185-93. PMID: 8977321

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-H2-I/Eκ Antibody (17-3-3) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-H2-I/Eκ Antibody (17-3-3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

H2-I/Eκ Antibody (17-3-3) Specifications

Alternate Product Name: H2-I/Eκ

Product Clone Name: 17-3-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a

Amino Acids:

Epitope Target: H2-I/Eκ

Epitope Species: mouse

Product Reactivity/Detection: H2-I/Eκ alloantigen on cells of the H-2r haplotype

Species Reactivity/Detection: mouse

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: FCM

Vialing Information: Each vial contains 100 µg IgG_2a in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for H2-I/Eκ Antibody (17-3-3): PE: Phycoerythrin

The preferred H2-I-A/I-E antibody is H2-I-A/I-E Antibody (M5/114): sc-23940.