H2-Dd Antibody (5K47): sc-71200
- H2-Dd Antibody (5K47) is a mouse monoclonal IgG2a provided at 100 µg/ml
- raised against C57BL/6 x DBA/2 F1 hybrid spenocytes of mouse origin
- recommended for detection of a conformational epitope on H2-Dd MHC class I found on the N terminal domains of α1 and α2 chains when complexed with β2 microglobulin of mouse origin by IP and FCM; non cross-reactive with H2Dd α chains synthesized in vitro
- available conjugated to FITC for IF, IHC(P) and FCM
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for H2-Dd Antibody (5K47). This work is in progress.
H2-Dd Antibody (5K47) is a mouse monoclonal IgG2a antibody that detects H2-Dd in mouse samples through immunoprecipitation (IP) and flow cytometry (FCM) applications. H2-Dd is a crucial component of the major histocompatibility complex (MHC) class I molecules, which play a vital role in the immune response by presenting foreign antigens to cytotoxic T lymphocytes (CTLs). The structure of H2-Dd, consisting of a heavy chain and a non-covalently associated beta-2 microglobulin, is essential for its function in antigen presentation. This structural configuration allows H2-Dd to effectively bind and present peptide fragments derived from intracellular proteins, thereby activating CTLs to target and eliminate infected or malignant cells. The ability of H2-Dd to interact with specific receptors, such as murine Ly-49D and Ly-49A, further underscores H2-Dd′s importance in modulating immune responses and maintaining self-tolerance. Using anti-H2-Dd antibody (5K47), researchers can gain valuable insights into the mechanisms of immune recognition and the role of MHC molecules in various immunological processes.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
H2-Dd Antibody (5K47) | sc-71200 | 100 µg/ml | $322.00 | |||
H2-Dd Antibody (5K47) FITC | sc-71200 FITC | 100 tests in 2 ml | $336.00 |