Date published: 2026-5-9

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H1-7 (histone H1 phosphorylation site), PKA Substrate (CAS 65189-70-0)

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Alternate Names:
Histone H1 phosphorylation site; PKA substrate; Arg-Arg-Lys-Ala-Ser-Gly-Pro; RRKASGP
Application:
H1-7 (histone H1 phosphorylation site), PKA Substrate is a synthetic peptide PKA substrate
CAS Number:
65189-70-0
Purity:
>97%
Molecular Weight:
770.9
Molecular Formula:
C31H58N14O9
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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H1-7 (histone H1 phosphorylation site), PKA Substrate is a synthetic peptide that acts as a pseudo substrate for PKA (cAMP-dependent protein kinase). This peptide was derived from the calf thymus histone H1 amino acid sequence about serine-38 and was used to research the reaction mechanism of the PKA catalytic subunit. H1-7 exhibits a greater absolute catalytic rate of phosphorylation than H1, an absolute Michaelis constant 40-fold greater than whole histone H1, but exhibits less affinity. Peptide sequence of H1-7: RRKASGP.


H1-7 (histone H1 phosphorylation site), PKA Substrate (CAS 65189-70-0) References

  1. Occurrence of epsilon-poly-L-lysine-degrading enzyme in epsilon-poly-L-lysine-tolerant Sphingobacterium multivorum OJ10: purification and characterization.  |  Kito, M., et al. 2002. FEMS Microbiol Lett. 207: 147-51. PMID: 11958932
  2. Purification and characterization of an epsilon-poly-L-lysine-degrading enzyme from an epsilon-poly-L-lysine-producing strain of Streptomyces albulus.  |  Kito, M., et al. 2002. Arch Microbiol. 178: 325-30. PMID: 12375099
  3. A broad-spectrum peptide inhibitor of beta-lactamase identified using phage display and peptide arrays.  |  Huang, W., et al. 2003. Protein Eng. 16: 853-60. PMID: 14631075
  4. Studies on the mechanism of phosphorylation of synthetic polypeptides by a calf thymus cyclic AMP-dependent protein kinase.  |  Pomerantz, AH., et al. 1977. Proc Natl Acad Sci U S A. 74: 4261-5. PMID: 200911
  5. Dipeptidyl peptidase III: a multifaceted oligopeptide N-end cutter.  |  Prajapati, SC. and Chauhan, SS. 2011. FEBS J. 278: 3256-76. PMID: 21794094
  6. EPRS is a critical mTORC1-S6K1 effector that influences adiposity in mice.  |  Arif, A., et al. 2017. Nature. 542: 357-361. PMID: 28178239

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

H1-7 (histone H1 phosphorylation site), PKA Substrate, 1 mg

sc-201152
1 mg
$112.00