Date published: 2025-10-13

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H-Trisaccharide

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Alternate Names:
H Type II Trisaccharide; Blood group H trisaccharide; Fuca1-2Galb1-3GlcNAc
Application:
H-Trisaccharide is a human blood group H type trisaccharide
Purity:
≥95%
Molecular Weight:
529.49
Molecular Formula:
C20H35NO15
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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H-Trisaccharide is a carbohydrate structure consisting of three monosaccharides linked together, typically forming a distinct oligosaccharide unit. The "H" designation generally refers to a specific trisaccharide associated with blood group antigens. In this structure, the core oligosaccharide chain is linked to a lipid or protein backbone, which plays a significant role in cell recognition and communication. In research, H-Trisaccharide has been instrumental in studying glycobiology, particularly for elucidating the mechanisms of cell-cell interactions and the role of carbohydrate moieties in molecular recognition. Studies of this trisaccharide are crucial for understanding the biosynthesis of more complex glycan structures. This understanding informs the structural elucidation of glycoconjugates and the development of advanced glycomics techniques. Furthermore, this trisaccharide serves as a valuable tool for investigating glycosyltransferase enzymes responsible for synthesizing complex glycans. It provides a model substrate for enzyme kinetics and the exploration of glycan biosynthesis pathways. Additionally, it has been used in the synthesis of neoglycoconjugates to probe carbohydrate-mediated binding interactions. These studies have broad implications for identifying key glycosylation sites and developing novel carbohydrate-based molecular probes and diagnostics.


H-Trisaccharide References

  1. Identification and localization of a schistosome-associated fucosyllactose determinant expressed by Fasciola hepatica.  |  Abdul-Salam, F. and Mansour, MH. 2000. Comp Immunol Microbiol Infect Dis. 23: 99-111. PMID: 10670699
  2. Interactions of the fucose-specific Pseudomonas aeruginosa lectin, PA-IIL, with mammalian glycoconjugates bearing polyvalent Lewis(a) and ABH blood group glycotopes.  |  Wu, AM., et al. 2006. Biochimie. 88: 1479-92. PMID: 16762477
  3. The interaction of a carbohydrate-binding module from a Clostridium perfringens N-acetyl-beta-hexosaminidase with its carbohydrate receptor.  |  Ficko-Blean, E. and Boraston, AB. 2006. J Biol Chem. 281: 37748-57. PMID: 16990278
  4. Molecular dynamics simulation of Lewis blood groups and related oligosaccharides.  |  Mukhopadhyay, C. and Bush, CA. 1991. Biopolymers. 31: 1737-46. PMID: 1793812
  5. Antigen recognition by variable lymphocyte receptors.  |  Han, BW., et al. 2008. Science. 321: 1834-7. PMID: 18818359
  6. Interaction of Naja naja atra cardiotoxin 3 with H-trisaccharide modulates its hemolytic activity and membrane-damaging activity.  |  Kao, PH., et al. 2010. Toxicon. 55: 1387-95. PMID: 20193704
  7. Overexpression, crystallization and preliminary X-ray crystallographic analysis of the variable lymphocyte receptor 2913 ectodomain fused with internalin B.  |  Lee, JY., et al. 2013. Acta Crystallogr Sect F Struct Biol Cryst Commun. 69: 39-41. PMID: 23295483
  8. Lectin activity of the pneumococcal pilin proteins.  |  Day, CJ., et al. 2017. Sci Rep. 7: 17784. PMID: 29259314
  9. The jelly layers and cortex of the unfertilized Xenopus laevis egg: carbohydrate, phospholipid and protein analysis.  |  Tilley, L., et al. 1988. Eur J Cell Biol. 47: 47-52. PMID: 3229420
  10. Purification and characterization of SM 37: a fucosyllactose determinant-bearing glycoprotein probed by a Biomphalaria alexandrina lectin on adult male schistosomes.  |  Mansour, MH. 1996. J Parasitol. 82: 586-93. PMID: 8691365

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

H-Trisaccharide, 1 mg

sc-300786
1 mg
$250.00