Molecular structure of H-Gly-Pro-Arg-Pro-OH Acetate Salt, CAS Number: 67869-62-9
H-Gly-Pro-Arg-Pro-OH Acetate Salt (CAS 67869-62-9)
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Application:
H-Gly-Pro-Arg-Pro-OH Acetate Salt is an inhibitor of fibrinogen aggregation and fibrin polymerization
CAS Number:
67869-62-9
Purity:
≥98%
Molecular Weight:
425.5 (free base)
Molecular Formula:
C18H31N7O5•C2H4O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
H-Gly-Pro-Arg-Pro-OH Acetate Salt can bind to the polymerization site (D domain) in fibrinogen (Ki = 400 mM) and prevent fibrinogen aggregation and fibrin polymerization. It also acts as an anticoagulant. Research shows that there is additional proteolysis of alpha, beta and gamma fibrinogen polypeptides during the cleavage of fibrinogen, which may also include the initial removal of fibrinopeptides.
H-Gly-Pro-Arg-Pro-OH Acetate Salt (CAS 67869-62-9) References
- High-density lipoproteins inhibit fibrinogen binding on adenosine diphosphate-activated monocytes. | Neufeld, M., et al. 2000. Blood Coagul Fibrinolysis. 11: 505-9. PMID: 10997789
- Formaldehyde-fixation of platelets for flow cytometric measurement of phosphatidylserine exposure is feasible. | Rochat, S. and Alberio, L. 2015. Cytometry A. 87: 32-6. PMID: 25266200
- Synthetic peptide derivatives that bind to fibrinogen and prevent the polymerization of fibrin monomers. | Laudano, AP. and Doolittle, RF. 1978. Proc Natl Acad Sci U S A. 75: 3085-9. PMID: 277910
- Gly-Pro-Arg-Pro modifies the glutamine residues in the alpha- and gamma-chains of fibrinogen: inhibition of transglutaminase cross-linking. | Achyuthan, KE., et al. 1986. Biochim Biophys Acta. 872: 261-8. PMID: 2873839
- Fibrin Modulates Shear-Induced NETosis in Sterile Occlusive Thrombi Formed under Haemodynamic Flow. | Yu, X. and Diamond, SL. 2019. Thromb Haemost. 119: 586-593. PMID: 30722079
- Core and shell platelets of a thrombus: A new microfluidic assay to study mechanics and biochemistry. | DeCortin, ME., et al. 2020. Res Pract Thromb Haemost. 4: 1158-1166. PMID: 33134782
- Identification of the factor XII contact activation site enables sensitive coagulation diagnostics. | Heestermans, M., et al. 2021. Nat Commun. 12: 5596. PMID: 34552086
- Fibrin Polymerization. 1. Alkylating peptide inhibitors of fibrin polymerization. | Hsieh, KH., et al. 1981. J Med Chem. 24: 322-7. PMID: 7265118
- Fasciola hepatica cathepsin L proteinase cleaves fibrinogen and produces a novel type of fibrin clot. | Dowd, AJ., et al. 1995. Eur J Biochem. 232: 241-6. PMID: 7556157
- Prevention of the influence of fibrin and alpha2-macroglobulin in the continuous measurement of the thrombin potential: implications for an endpoint determination of the optical density. | Rijkers, DT., et al. 1998. Thromb Res. 89: 161-9. PMID: 9651143
Inhibitor of:
Angiogenesis.Activator of:
Factor XIII B.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
H-Gly-Pro-Arg-Pro-OH Acetate Salt, 5 mg | sc-203071 | 5 mg | $72.00 |