H-D-Val-Leu-Arg-AFC
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H-D-Val-Leu-Arg-AFC is a substrate commonly used in enzymatic assays to measure the activity of proteases. When added to a reaction mixture containing the enzyme of interest, H-D-Val-Leu-Arg-AFC is cleaved by the protease, releasing a fluorescent compound. This allows for the quantification of protease activity, as the increase in fluorescence is directly proportional to the amount of substrate cleaved. The mode of action of H-D-Val-Leu-Arg-AFC involves its specific recognition and cleavage by the target protease, resulting in the release of the fluorescent compound. This chemical is particularly useful in studying the activity of various proteases in both in vitro and in vivo experimental applications, providing valuable insights into their function and regulation. Its ability to accurately measure protease activity makes it a valuable in the field of enzymology and protease research.
H-D-Val-Leu-Arg-AFC References
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- A Novel, Nonpeptidic, Orally Active Bivalent Inhibitor of Human β-Tryptase. | Giardina, SF., et al. 2018. Pharmacology. 102: 233-243. PMID: 30134249
- Renal release of N-acetyl-seryl-aspartyl-lysyl-proline is part of an antifibrotic peptidergic system in the kidney. | Romero, CA., et al. 2019. Am J Physiol Renal Physiol. 316: F195-F203. PMID: 30403163
- Novel, Self-Assembling Dimeric Inhibitors of Human β Tryptase. | Giardina, SF., et al. 2020. J Med Chem. 63: 3004-3027. PMID: 32057241
- Plasma contact factors as novel biomarkers for diagnosing Alzheimer's disease. | Park, JE., et al. 2021. Biomark Res. 9: 5. PMID: 33422144
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
H-D-Val-Leu-Arg-AFC, 1 mg | sc-391026 | 1 mg | $130.00 | |||
H-D-Val-Leu-Arg-AFC, 5 mg | sc-391026A | 5 mg | $525.00 |