Molecular structure of H-9 hydrochloride, CAS Number: 116970-50-4
H-9 hydrochloride (CAS 116970-50-4)
Application:
H-9 hydrochloride is a potent and competitive inhibitor of protein kinase C, cAMP-dependent protein kinase, and cGMP
CAS Number:
116970-50-4
Purity:
>99%
Molecular Weight:
287.77
Molecular Formula:
C11H13N3O2S•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
H-9 hydrochloride inhibits PKA (Ki=1.9 muM), PKC (Ki=18 muM cGKI (PKG) =0.87 muM MLCK=70 muM). It has shown to dramatically reduce the GABA response of GABAA currents in retinal rod bipolar cells as well as inhibit smooth muscle cell relaxation induced by cGRP. H-9 dihydrochloride has also been used for purification of protein kinases in ligand affinity chromatography.
H-9 hydrochloride (CAS 116970-50-4) References
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- Chemosensitization to cisplatin by inhibitors of the Fanconi anemia/BRCA pathway. | Chirnomas, D., et al. 2006. Mol Cancer Ther. 5: 952-61. PMID: 16648566
- Inhibition of β-catenin signaling by nongenomic action of orphan nuclear receptor Nur77. | Sun, Z., et al. 2012. Oncogene. 31: 2653-67. PMID: 21986938
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- The underlying molecular mechanism and drugs for treatment in adrenal cortical carcinoma. | Ma, C., et al. 2021. Int J Med Sci. 18: 3026-3038. PMID: 34220331
- Interaction of protein kinase C with membranes is regulated by Ca2+, phorbol esters, and ATP. | Wolf, M., et al. 1985. J Biol Chem. 260: 15718-22. PMID: 4066694
- Protein kinase modulation of GABAA currents in rabbit retinal rod bipolar cells. | Gillette, MA. and Dacheux, RF. 1996. J Neurophysiol. 76: 3070-86. PMID: 8930256
- Ceramide-mediated and isoquinolinesulfonamide-sensitive pathways of neuronal death: anything in common? | Manev, H. and Cagnoli, CM. 1997. Neurochem Int. 31: 203-6. PMID: 9220452
- The cholinergic gene locus is coordinately regulated by protein kinase A II in PC12 cells. | Shimojo, M., et al. 1998. J Neurochem. 71: 1118-26. PMID: 9721736
- Calcitonin gene-related peptide-induced relaxation of isolated human colonic smooth muscle cells through different intracellular pathways. | Boyer, JC., et al. 1998. Biochem Pharmacol. 56: 1097-104. PMID: 9802318
Inhibitor of:
cGKI, MYLK, PKA, PKC, and Ser/Thr Protein Kinase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
H-9 hydrochloride, 10 mg | sc-200553 | 10 mg | $79.00 | |||
H-9 hydrochloride, 50 mg | sc-200553A | 50 mg | $323.00 |