Molecular structure of H-7, CAS Number: 84477-87-2
H-7 (CAS 84477-87-2)
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Alternate Names:
1-(5-Isoquinolinesulfonyl)-2-methylpiperazine; Isoquinoline-5-sulfonic 2-methyl-1-piperazide
Application:
H-7 is An inhibitor of PKA and PKC
CAS Number:
84477-87-2
Molecular Weight:
291.37
Molecular Formula:
C14H17N3O2S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
H-7 is an inhibitor of the cyclic nucleotide dependent protein kinases PKA and PKC. Therefore, it can disrupt cell signaling, gene expression, glucose metabolism, cell proliferation and growth, neurotransmitter signaling, apoptosis, and immune responses. It is also an inhibitor of carbonic anhydrase I and II, which results in a decrease in the production of carbonic acid. Additionally, H-7 inhibits the enzyme trypsin, so it can be used to interfere with the breakdown of proteins or to detach adherent cells from culture surfaces.
H-7 (CAS 84477-87-2) References
- The protein kinase inhibitor, H-7, suppresses heat induced activation of heat shock transcription factor 1. | Ohnishi, K., et al. 1999. Mol Cell Biochem. 197: 129-35. PMID: 10485332
- Protein kinase C affects microfilaments, bone resorption, and [Ca2+]o sensing in cultured osteoclasts. | Teti, A., et al. 1992. Am J Physiol. 263: C130-9. PMID: 1636672
- Design of potent protein kinase inhibitors using the bisubstrate approach. | Ricouart, A., et al. 1991. J Med Chem. 34: 73-8. PMID: 1992155
- Vasoactive intestinal peptide suppresses macrophage-mediated inflammation by downregulating interleukin-17A expression via PKA- and PKC-dependent pathways. | Ran, WZ., et al. 2015. Int J Exp Pathol. 96: 269-75. PMID: 25944684
- Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C. | Hidaka, H., et al. 1984. Biochemistry. 23: 5036-41. PMID: 6238627
- Effect of protein kinase inhibitor H-7 on the contractility, integrity, and membrane anchorage of the microfilament system. | Volberg, T., et al. 1994. Cell Motil Cytoskeleton. 29: 321-38. PMID: 7859295
- Effects of activators (SC-9 and OAG) and inhibitors (staurosporine and H-7) of protein kinase C on the proliferation of mouse epidermal melanoblasts in serum-free culture. | Hirobe, T. 1994. J Cell Sci. 107 (Pt 6): 1679-86. PMID: 7962208
- Regulation of mucin secretion in T84 adenocarcinoma cells by forskolin: relationship to Ca2+ and PKC. | Forstner, G., et al. 1994. Am J Physiol. 266: G606-12. PMID: 8178999
- Signal transduction in avian granulosa cells: effects of protein kinase C inhibitors. | Jamaluddin, M., et al. 1994. Gen Comp Endocrinol. 93: 471-9. PMID: 8194746
- Growth factors protect PC12 cells against ischemia by a mechanism that is independent of PKA, PKC, and protein synthesis. | Boniece, IR. and Wagner, JA. 1993. J Neurosci. 13: 4220-8. PMID: 8410184
- M1 muscarinic receptor-induced facilitation of ACh and noradrenaline release in the rat bladder is mediated by protein kinase C. | Somogyi, GT., et al. 1996. J Physiol. 496 (Pt 1): 245-54. PMID: 8910212
- Seasonal fluctuations in the secretory response of neuroendocrine cells of Aplysia californica to inhibitors of protein kinase A and protein kinase C. | Wayne, NL., et al. 1998. Gen Comp Endocrinol. 109: 356-65. PMID: 9480743
- H-7-induced apoptosis in the cells of a Drosophila neuronal cell line through affecting unidentified H-7-sensitive substance(s). | Nagano, M., et al. 1998. Neurosci Res. 31: 113-21. PMID: 9700717
Inhibitor of:
PKA, PKC, and Ser/Thr Protein Kinase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
H-7, 5 mg | sc-215123 | 5 mg | $326.00 |