Molecular structure of H-1152 dihydrochloride, CAS Number: 451462-58-1
H-1152 dihydrochloride (CAS 451462-58-1)
See product citations (7)
Alternate Names:
(S)-(+)-2-Methyl-1-[(4-methyl-5-isoquinolinyl)sulfonyl]homopiperazine . 2HCl
Application:
H-1152 dihydrochloride is a cell permeable, highly specific, and potent ATP-competitive inhibitor of ρ-kinase inhibitor
CAS Number:
451462-58-1
Purity:
≥98%
Molecular Weight:
392.34
Molecular Formula:
C16H21N3O2S•2HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
H-1152 dihydrochloride is a selective ATP-competitive inhibitor of rho-kinase (ROCK) inhibitor, cell permeable, highly specific, and potent (Ki = 1.6 nM). Exhibits weaker affinity for other serine/threonine kinases (Ki = 630 nM for PKA, 9.27mM for PKC and 10.1 mM for MLCK) and is more potent and selective than Y-27632. Inhibits the phosphorylation of MARCKS in cells stimulated by lysophosphatidic acid and inhibits EP3-stimulated NO formation. H-1152. dihydrochloride prevents fragmentation of apoptotic cells. Relieves neuropathic pain.
H-1152 dihydrochloride (CAS 451462-58-1) References
- Mammary stem cells have myoepithelial cell properties. | Prater, MD., et al. 2014. Nat Cell Biol. 16: 942-50, 1-7. PMID: 25173976
- Influenza promotes collagen deposition via αvβ6 integrin-mediated transforming growth factor β activation. | Jolly, L., et al. 2014. J Biol Chem. 289: 35246-63. PMID: 25339175
- Differential contribution of calcium channels to α1-adrenoceptor-mediated contraction is responsible for diverse responses to cooling between rat tail and iliac arteries. | Ishida, H., et al. 2018. Eur J Pharmacol. 826: 9-16. PMID: 29458039
Inhibitor of:
α-actinin-4, ARHGAP (Rho GTPase activating protein), ARHGAP11B, ARHGAP15, ARHGAP36, ARHGAP39, ARHGAP40, cadherin-20, Calponin 1, Calponin 2, Calponin 3, DDEFL1, EG546400, EG625591, FRMD3, IRSp53, M-RIP, MIZIP, MLC, MLCKSK, Moesin, MRLC2, MRTF-A, MRVI1, MYH1, MYH2, MYH3, MYL10, Myl12a, MYL6, MYL6B, Mylc2b, MYLPF, Myosin Id, Myosin IIIa, Myosin VIIB, Myosin XVIIIa, Myosin-XVA, MYPT2, N-RAP, netrin-1, Neuron navigator 2, OXSR1, PCDHGA11, PCDHGB2, PHACTR4, PLEK2, PLEKHG6, rabphilin-11, RGMa, Rho 8, Rock, Rock-2, SLMAP, smoothelin, Ste20, SYDE1, TEF-3, THSD4, Tropomyosin, and ZO-1.Activator of:
βPIX, ARHGAP21, ARHGAP6, ARHGEF38, ARHGEF39, Coronin 1B, FRMD6, Myosin VI, Rho 7, Rho H, Rho J, RHOBTB1, tropomodulin 1, XPLN, and ZIP-kinase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
H-1152 dihydrochloride, 1 mg | sc-203592 | 1 mg | $104.00 | |||
H-1152 dihydrochloride, 5 mg | sc-203592A | 5 mg | $364.00 |