Molecular structure of GYY 4137, CAS Number: 106740-09-4
GYY 4137 (CAS 106740-09-4)
See product citations (12)
Alternate Names:
4-Methoxyphenyl(morpholino)phosphinodithioate morpholinium salt
Application:
GYY 4137 is a slow releasing hydrogen sulfide donor
CAS Number:
106740-09-4
Purity:
≥95%
Molecular Weight:
377.48
Molecular Formula:
C11H16NO2PS2•C4H10NO
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
GYY 4137 morpholine salt, also referred to as N-methyl-2-pyrrolidone-5-sulfonate, is an artificial substance extensively employed in various scientific research endeavors. It appears as a white crystalline powder that can dissolve in both water and organic solvents. Researchers believe that GYY 4137 morpholine salt operates as a regulator of biological processes, including enzyme activity, hormone production, and various cellular constituents. The compound is hypothesized to engage with specific proteins or receptors, influencing their function and consequently impacting the activity of other proteins or receptors.
GYY 4137 (CAS 106740-09-4) References
- Hydrogen sulfide inhibits Na+ uptake in larval zebrafish, Danio rerio. | Kumai, Y., et al. 2015. Pflugers Arch. 467: 651-64. PMID: 24939700
- Pharmacological Actions of Hydrogen Sulfide Donors on Sympathetic Neurotransmission in the Bovine Anterior Uvea, In Vitro. | Salvi, A., et al. 2016. Neurochem Res. 41: 1020-8. PMID: 26700431
- Hydrogen Sulfide Induced Erythropoietin Synthesis is Regulated by HIF Proteins. | Leigh, J., et al. 2016. J Urol. 196: 251-60. PMID: 26880412
- Effect of Hydrogen Sulfide Donors on Intraocular Pressure in Rabbits. | Salvi, A., et al. 2016. J Ocul Pharmacol Ther. 32: 371-5. PMID: 27092593
- Sustained-Release Delivery System of a Slow Hydrogen Sulfide Donor, GYY 4137, for Potential Application in Glaucoma. | Patil, A., et al. 2017. AAPS PharmSciTech. 18: 2291-2302. PMID: 28101725
- Hydrogen sulphide facilitates exocytosis by regulating the handling of intracellular calcium by chromaffin cells. | de Pascual, R., et al. 2018. Pflugers Arch. 470: 1255-1270. PMID: 29721607
- Experimental research into the potential therapeutic effect of GYY4137 on Ovariectomy-induced osteoporosis. | Xu, ZS., et al. 2018. Cell Mol Biol Lett. 23: 47. PMID: 30305826
- Improved growth of pea, lettuce, and radish plants using the slow release of hydrogen sulfide from GYY-4137. | Carter, JM., et al. 2018. PLoS One. 13: e0208732. PMID: 30557337
- Characterization of Dialkyldithiophosphates as Slow Hydrogen Sulfide Releasing Chemicals and Their Effect on the Growth of Maize. | Carter, JM., et al. 2019. J Agric Food Chem. 67: 11883-11892. PMID: 31596582
- The slow releasing hydrogen sulfide donor GYY4137 reduces neointima formation upon FeCl3 injury of the carotid artery in mice. | Grambow, E., et al. 2020. Clin Hemorheol Microcirc. 75: 409-417. PMID: 31929150
- Intraarticular Administration Effect of Hydrogen Sulfide on an In Vivo Rat Model of Osteoarthritis. | Vaamonde-García, C., et al. 2020. Int J Mol Sci. 21: PMID: 33050005
- Mechanism of preservation of the intestinal mucosa architecture and NF-κB/PGE2 reduction by hydrogen sulfide on cholera toxin-induced diarrhea in mice. | Sousa, FBM., et al. 2021. Life Sci. 284: 119869. PMID: 34358552
- Uremic Toxin Indoxyl Sulfate Impairs Hydrogen Sulfide Formation in Renal Tubular Cells. | Lu, CL., et al. 2022. Antioxidants (Basel). 11: PMID: 35204244
- Inhalative as well as Intravenous Administration of H2S Provides Neuroprotection after Ischemia and Reperfusion Injury in the Rats' Retina. | Scheid, S., et al. 2022. Int J Mol Sci. 23: PMID: 35628328
- Vasoactive Effects of Chronic Treatment with Fructose and Slow-Releasing H2S Donor GYY-4137 in Spontaneously Hypertensive Rats: The Role of Nitroso and Sulfide Signalization. | Berenyiova, A., et al. 2022. Int J Mol Sci. 23: PMID: 36012477
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GYY 4137, 10 mg | sc-224013 | 10 mg | $80.00 | |||
GYY 4137, 25 mg | sc-224013A | 25 mg | $214.00 | |||
GYY 4137, 50 mg | sc-224013B | 50 mg | $337.00 | |||
GYY 4137, 100 mg | sc-224013C | 100 mg | $588.00 |