Molecular structure of GW501516, CAS Number: 317318-70-0
GW501516 (CAS 317318-70-0)
See product citations (28)
Alternate Names:
2-[2-methyl-4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methylsulfanyl]phenoxy]acetic acid; Endurobol
Application:
GW501516 is a selective and potent PPARβ agonist
CAS Number:
317318-70-0
Purity:
≥97%
Molecular Weight:
453.50
Molecular Formula:
C21H18F3NO3S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
GW501516 is the most selective and potent PPARbeta (EC50=1.1nM) agonist that has been demonstrated to be 1,000-fold more selective in comparison to existing subtypes. Studies demonstrate that GW501516 can regulate expression of genes involved in lipid catabolism and energy uncoupling in skeletal muscle cells. Additionally, GW501516 may act to block insulin resistance and fatty acid-induced nuclear factor-kappaB (NF-κB) activation.
GW501516 (CAS 317318-70-0) References
- A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport. | Oliver, WR., et al. 2001. Proc Natl Acad Sci U S A. 98: 5306-11. PMID: 11309497
- Peroxisome proliferator-activated receptor (PPAR) alpha and PPARbeta/delta, but not PPARgamma, modulate the expression of genes involved in cardiac lipid metabolism. | Gilde, AJ., et al. 2003. Circ Res. 92: 518-24. PMID: 12600885
- Novel selective small molecule agonists for peroxisome proliferator-activated receptor delta (PPARdelta)--synthesis and biological activity. | Sznaidman, ML., et al. 2003. Bioorg Med Chem Lett. 13: 1517-21. PMID: 12699745
- The peroxisome proliferator-activated receptor beta/delta agonist, GW501516, regulates the expression of genes involved in lipid catabolism and energy uncoupling in skeletal muscle cells. | Dressel, U., et al. 2003. Mol Endocrinol. 17: 2477-93. PMID: 14525954
- A short and efficient synthesis of the pharmacological research tool GW501516 for the peroxisome proliferator-activated receptor delta. | Wei, ZL. and Kozikowski, AP. 2003. J Org Chem. 68: 9116-8. PMID: 14604391
- Synthesis of the PPARbeta/delta-selective agonist GW501516 and C4-thiazole-substituted analogs. | Pereira, R., et al. 2006. Bioorg Med Chem Lett. 16: 49-54. PMID: 16242326
- Effects of bezafibrate, PPAR pan-agonist, and GW501516, PPARdelta agonist, on development of steatohepatitis in mice fed a methionine- and choline-deficient diet. | Nagasawa, T., et al. 2006. Eur J Pharmacol. 536: 182-91. PMID: 16574099
- The PPARdelta agonist, GW501516, promotes fatty acid oxidation but has no direct effect on glucose utilisation or insulin sensitivity in rat L6 skeletal muscle cells. | Dimopoulos, N., et al. 2007. FEBS Lett. 581: 4743-8. PMID: 17869249
- Activation of peroxisome proliferator-activated receptor-{delta} by GW501516 prevents fatty acid-induced nuclear factor-{kappa}B activation and insulin resistance in skeletal muscle cells. | Coll, T., et al. 2010. Endocrinology. 151: 1560-9. PMID: 20185762
- The peroxisome proliferator-activated receptor β/Δ (PPARβ/Δ) agonist GW501516 prevents TNF-α-induced NF-κB activation in human HaCaT cells by reducing p65 acetylation through AMPK and SIRT1. | Barroso, E., et al. 2011. Biochem Pharmacol. 81: 534-43. PMID: 21146504
- GW501516, a PPARΔ agonist, ameliorates tubulointerstitial inflammation in proteinuric kidney disease via inhibition of TAK1-NFκB pathway in mice. | Yang, X., et al. 2011. PLoS One. 6: e25271. PMID: 21966476
- The peroxisome proliferator-activated receptor (PPAR) β/Δ agonist GW501516 inhibits IL-6-induced signal transducer and activator of transcription 3 (STAT3) activation and insulin resistance in human liver cells. | Serrano-Marco, L., et al. 2012. Diabetologia. 55: 743-51. PMID: 22179221
- GW501516-activated PPARβ/Δ promotes liver fibrosis via p38-JNK MAPK-induced hepatic stellate cell proliferation. | Kostadinova, R., et al. 2012. Cell Biosci. 2: 34. PMID: 23046570
- Short-term administration of GW501516 improves inflammatory state in white adipose tissue and liver damage in high-fructose-fed mice through modulation of the renin-angiotensin system. | Magliano, DC., et al. 2015. Endocrine. 50: 355-67. PMID: 25854303
- A metabolomic study of the PPARΔ agonist GW501516 for enhancing running endurance in Kunming mice. | Chen, W., et al. 2015. Sci Rep. 5: 9884. PMID: 25943561
Inhibitor of:
β3Gn-T2, 2200002K05Rik, 2310042D19Rik, 4921511M17Rik, 4921528O07Rik, 4933421E11Rik, Angptl2, ARA54, ATAD3C, C/EBP δ, C10orf12, C2orf73, C2orf79, C2orf80, C3orf43, C3orf72, Dystrophin-Glycoprotein Complex (DGC; Sarcospan), EG384813, Esgp, Esp34, Esp36, Esp8, FACL6, GDF-8, LOC55908, mPRγ, NR3B, Olr482, OR5M9, PLC β3, PTRH2, RFLAT-1, SARM, SEC14L3, SP140, TMEM18, TR2, TRIM77, TUSC5, UPLP, ZEB2, and Zimp10.Activator of:
β-Dystrobrevin, 17β-HSD13, 2310042D19Rik, 2900097C17Rik, ABCD3, ABCG8, ABHD13, ABHD15, ABHD3, ABHD5, ACADSB, ACOX1, ACOXL, ACSBG2, ACSF1, apoD, apoM, ARK-2, BCAT2, C18orf19, CC10, CEACAM1, Ces1a, CoREST, Cyp2c38, Cyp2c40, CYP2J8, CYP4A10, CYP4A12B, D10Jhu81e, D830030K20Rik, DBT, EDG-2, EG329055, EG432995, EG624219, EG624584, EMBP, FADS2, FGF-19, FHL-2, FHL1, FOXL2, GDF8, GP-39, GRAMD1C, Hic-5, HSDL2, KNDC1, L-FABP, LCOR, Lipin-2, LPAAT-η, LRIF, LSDP5, MBNL1, MCAD, megalin, MFSD6, MFSD6L, MLYCD, MRP-L21, MRPL28, MTP, MUP, MURC, Musclin, Myf-5, Myf-6, MYH6, MYH8, myocilin, Myotilin, NARC-1, nephrocystin-4, Nix, Nkx-2.5, NT-3, Nurr1, PDC-E2, PGC-1α, PJA2, POU3F4, PPAR beta, pUb-R, Ran BP-2, resistin, SCD2, SCP-2, SDSL, SLC25A33, SP-C, SRRD, ST2, TARSL1, TBC1D1, Telethonin, THP, Titin, TMEM170, TMEM41A, Troponin T-FS, UNC45B, USP18, VARS2, VDAC2, and ZBTB42.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GW501516, 1 mg | sc-202642 | 1 mg | $80.00 | |||
GW501516, 5 mg | sc-202642A | 5 mg | $175.00 |