Molecular structure of GW 9578, CAS Number: 247923-29-1
GW 9578 (CAS 247923-29-1)
Alternate Names:
2- [[4- [2- [[[(2, 4- difluorophenyl)amino]carbonyl]heptylamino]ethyl]phenyl]thio]- 2- methyl- propanoic acid
Application:
GW 9578 is a potent agonist of PPARα
CAS Number:
247923-29-1
Molecular Weight:
492.6
Molecular Formula:
C26H34F2N2O3S
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
A potent agonist of PPARα that activates the murine and human receptors with EC50 values of 0.005 and 0.05 µM, respectively.4 GW 9578 is highly selective for PPARα compared to PPARγ and PPARδ.4 GW 9578 is a potent lipid lowering agent that may reduce insulin resistance. When 0.2 mg/kg GW 9578 was given orally once daily for three days, serum total LDL cholesterol was decreased 40-60% in male Sprague-Dawely rats.4 Obese Zucker rats treated with 5 mg/kg GW 9578 for nine days had markedly reduced serum insulin concentrations compared to controls.
GW 9578 (CAS 247923-29-1) References
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- The characterization of PPAR alpha ligand drug action in an in vivo model by comprehensive differential gene expression profiling. | Gould Rothberg, BE., et al. 2001. Funct Integr Genomics. 1: 294-304. PMID: 11793248
- Rat liver acyl-CoA synthetase 4 is a peripheral-membrane protein located in two distinct subcellular organelles, peroxisomes, and mitochondrial-associated membrane. | Lewin, TM., et al. 2002. Arch Biochem Biophys. 404: 263-70. PMID: 12147264
- Synthesis and biological activity of novel alpha-substituted beta-phenylpropionic acids having pyridin-2-ylphenyl moiety as antihyperglycemic agents. | Takamura, M., et al. 2004. Bioorg Med Chem. 12: 2419-39. PMID: 15080938
- A facile one-pot preparation of alkyl aminoaryl sulfides for the synthesis of GW7647 as an agonist of peroxisome proliferator-activated receptor alpha. | Ham, J., et al. 2006. J Org Chem. 71: 5781-4. PMID: 16839165
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- PPAR agonists modulate human osteoclast formation and activity in vitro. | Chan, BY., et al. 2007. Bone. 40: 149-59. PMID: 17010686
- The Effect of PPARalpha, PPARdelta, PPARgamma, and PPARpan Agonists on Body Weight, Body Mass, and Serum Lipid Profiles in Diet-Induced Obese AKR/J Mice. | Harrington, WW., et al. 2007. PPAR Res. 2007: 97125. PMID: 17710237
- Prostaglandin-D synthetase induces transcription of the LH beta subunit in the primary culture of chicken anterior pituitary cells via the PPAR signaling pathway. | Chen, LR., et al. 2010. Theriogenology. 73: 367-82. PMID: 19954828
- The Effect of PPAR Agonists on the Migration of Mature and Immature Eosinophils. | Smith, SG., et al. 2012. PPAR Res. 2012: 235231. PMID: 22966220
- Evaluation of peroxisome proliferator-activated receptor agonists on interleukin-5-induced eosinophil differentiation. | Smith, SG., et al. 2014. Immunology. 142: 484-91. PMID: 24628018
- Regulation of expression and role of peroxisome proliferator-activated receptors (PPARs) in luminal epithelial and stromal cells of the porcine endometrium. | Blitek, A. and Szymanska, M. 2019. Theriogenology. 127: 88-101. PMID: 30677596
Activator of:
PPAR alpha.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GW 9578, 500 µg | sc-221703 | 500 µg | $22.00 | |||
GW 9578, 1 mg | sc-221703A | 1 mg | $57.00 |