Molecular structure of GW 627368X, CAS Number: 439288-66-1
GW 627368X (CAS 439288-66-1)
See product citations (3)
Alternate Names:
4-(4,9-diethoxy-1,3-dihydro-1-oxo-2H-benz[f]isoindol-2-yl)-N-(phenylsulfonyl)-benzeneacetamide
Application:
GW 627368X is a selective and potent competitive antagonist of the EP4 receptor
CAS Number:
439288-66-1
Purity:
>96%
Molecular Weight:
544.62
Molecular Formula:
C30H28N2O6S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
The effects of prostaglandin E2 (PGE2) are transduced by at least four different receptors designated EP1, EP2, EP3, and EP4 (1). GW 627368X is a selective and potent competitive antagonist of the EP4 receptor with additional human TP receptor affinity. In competition radioligand bioassays, GW 627368X had affinity for human TP and EP4 receptors with Ki values of 158 nM and 100 nM, respectively (2). Affinity for all other human prostanoid receptors is higher than 5.0 µM. In human washed platelets, GW 627368X produced 100% inhibition of U-46619 (EC100)-induced aggregation at a concentration of 10 µM.
GW 627368X (CAS 439288-66-1) References
1 Coleman, R.A., Smith, W.L., Narumiya, S. Classification of prostanoid receptors: Properties, distribution, and structure of the receptors and their subtypes. Pharmacol Rev 46 205-229 (1994). 2 Wilson, R.J., Giblin, G.M.P., Roomans, S., et al. GW627368X ((N-{2-[4-(4,9-diethoxy-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)phenyl]acetyl} benzene sulphonamide): A novel, potent and selective prostanoid EP4 receptor antagonist. Br J Pharmacol 148 326-339 (2006).Inhibitor of:
EP4.Activator of:
EP2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GW 627368X, 1 mg | sc-221702 | 1 mg | $94.00 | |||
GW 627368X, 5 mg | sc-221702A | 5 mg | $423.00 |