Molecular structure of GW-405833, CAS Number: 180002-83-9
GW-405833 (CAS 180002-83-9)
Application:
GW-405833 is a CB2 partial agonist
CAS Number:
180002-83-9
Purity:
97%
Molecular Weight:
447.4
Molecular Formula:
C23H24Cl2N2O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
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Description
Technical Information
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SDS & Certificate of Analysis
GW-405833 binds to both rat and human CB2 receptors where it acts as a partial agonist. It elicits potent and efficacious antihyperalgesic effects in rodent models of neuropathic, incisional and chronic inflammatory pain. Its antinociceptive properties are opioid independent. It displays anti-inflammatory effects in vivo.
GW-405833 (CAS 180002-83-9) References
- CB1 and CB2 cannabinoid receptors are implicated in inflammatory pain. | Clayton, N., et al. 2002. Pain. 96: 253-260. PMID: 11972997
- Pharmacological and pharmacokinetic characterization of the cannabinoid receptor 2 agonist, GW405833, utilizing rodent models of acute and chronic pain, anxiety, ataxia and catalepsy. | Valenzano, KJ., et al. 2005. Neuropharmacology. 48: 658-72. PMID: 15814101
- A role for cannabinoid receptors, but not endogenous opioids, in the antinociceptive activity of the CB2-selective agonist, GW405833. | Whiteside, GT., et al. 2005. Eur J Pharmacol. 528: 65-72. PMID: 16316650
- Cannabinoid CB2 receptor agonist activity in the hindpaw incision model of postoperative pain. | LaBuda, CJ., et al. 2005. Eur J Pharmacol. 527: 172-4. PMID: 16316653
- Depression-like behaviour in rats with mononeuropathy is reduced by the CB2-selective agonist GW405833. | Hu, B., et al. 2009. Pain. 143: 206-212. PMID: 19345493
- Paradoxical effects of the cannabinoid CB2 receptor agonist GW405833 on rat osteoarthritic knee joint pain. | Schuelert, N., et al. 2010. Osteoarthritis Cartilage. 18: 1536-43. PMID: 20863899
- Synthesis, in vitro and in vivo evaluation of fluorine-18 labelled FE-GW405833 as a PET tracer for type 2 cannabinoid receptor imaging. | Evens, N., et al. 2011. Bioorg Med Chem. 19: 4499-505. PMID: 21737287
- Characterization of cannabinoid receptor ligands in tissues natively expressing cannabinoid CB2 receptors. | Marini, P., et al. 2013. Br J Pharmacol. 169: 887-99. PMID: 23711022
- Cannabinoid CB2 Agonist GW405833 Suppresses Inflammatory and Neuropathic Pain through a CB1 Mechanism that is Independent of CB2 Receptors in Mice. | Li, AL., et al. 2017. J Pharmacol Exp Ther. 362: 296-305. PMID: 28592614
- Modulation of gastric acid secretion by cannabinoids in rats. | Salama, RAA., et al. 2019. J Biochem Mol Toxicol. 33: e22256. PMID: 30381869
- The exogenous administration of CB2 specific agonist, GW405833, inhibits inflammation by reducing cytokine production and oxidative stress. | Parlar, A., et al. 2018. Exp Ther Med. 16: 4900-4908. PMID: 30542446
- Protective effects of specific cannabinoid receptor 2 agonist GW405833 on concanavalin A-induced acute liver injury in mice. | Huang, ZB., et al. 2019. Acta Pharmacol Sin. 40: 1404-1411. PMID: 30918343
- Protective effect of cannabinoids on gastric mucosal lesions induced by water immersion restrain stress in rats. | Elgohary, R., et al. 2021. Iran J Basic Med Sci. 24: 1182-1189. PMID: 35083004
- A CB2 Receptor Agonist Reduces the Production of Inflammatory Mediators and Improves Locomotor Activity in Experimental Autoimmune Encephalomyelitis. | Parastouei, K., et al. 2022. Rep Biochem Mol Biol. 11: 1-9. PMID: 35765518
Activator of:
CB2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GW-405833, 10 mg | sc-200373 | 10 mg | $102.00 | |||
| US: Only available in the US | ||||||
GW-405833, 50 mg | sc-200373A | 50 mg | $319.00 | |||
| US: Only available in the US | ||||||