Molecular structure of GW 3965 hydrochloride, CAS Number: 405911-17-3
GW 3965 hydrochloride (CAS 405911-17-3)
Alternate Names:
GW 3965 hydrochloride is known as a liver X receptor agonist.
Application:
GW 3965 hydrochloride is an orally-active, non-steroidal liver X receptor (LXR) agonist that can also suppress angiotensin II.
CAS Number:
405911-17-3
Purity:
≥98%
Molecular Weight:
618.51
Molecular Formula:
C33H31F3ClNO3•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
GW 3965 hydrochloride is a non-steroidal agonist of liver X receptor (LXR), which specifically induces hLXRα and hLXRβ. Cell-free ligand-sensing assays involving GW 3965 hydrochloride indicate that hLXRα is favored over hLXRβ. Alternate studies suggest that GW 3965 hydrochloride upregulates ABCA1 in low density lipoprotein-loaded macrophages. Since ABCA1 is a major regulator of cholesterol and phospholipid metabolism, GW 3965 hydrochloride is a useful tool to study these cellular functions. In addition, GW 3965 hydrochloride suppresses angiotensin II.
GW 3965 hydrochloride (CAS 405911-17-3) References
- Identification of a nonsteroidal liver X receptor agonist through parallel array synthesis of tertiary amines. | Collins, JL., et al. 2002. J Med Chem. 45: 1963-6. PMID: 11985463
- Synthetic LXR ligand inhibits the development of atherosclerosis in mice. | Joseph, SB., et al. 2002. Proc Natl Acad Sci U S A. 99: 7604-9. PMID: 12032330
- Reciprocal regulation of inflammation and lipid metabolism by liver X receptors. | Joseph, SB., et al. 2003. Nat Med. 9: 213-9. PMID: 12524534
- GW3965, a synthetic liver X receptor (LXR) agonist, reduces angiotensin II-mediated pressor responses in Sprague-Dawley rats. | Leik, CE., et al. 2007. Br J Pharmacol. 151: 450-6. PMID: 17420776
- Physiological differences between human and rat primary hepatocytes in response to liver X receptor activation by 3-[3-[N-(2-chloro-3-trifluoromethylbenzyl)-(2,2-diphenylethyl)amino]propyloxy]phenylacetic acid hydrochloride (GW3965). | Kotokorpi, P., et al. 2007. Mol Pharmacol. 72: 947-55. PMID: 17628011
- Liver X receptor agonist GW3965 dose-dependently regulates lps-mediated liver injury and modulates posttranscriptional TNF-alpha production and p38 mitogen-activated protein kinase activation in liver macrophages. | Wang, YY., et al. 2009. Shock. 32: 548-53. PMID: 19295476
- ATP-binding cassette transporter A1 mediates the beneficial effects of the liver X receptor agonist GW3965 on object recognition memory and amyloid burden in amyloid precursor protein/presenilin 1 mice. | Donkin, JJ., et al. 2010. J Biol Chem. 285: 34144-54. PMID: 20739291
- Liver X receptor modulates diabetic retinopathy outcome in a mouse model of streptozotocin-induced diabetes. | Hazra, S., et al. 2012. Diabetes. 61: 3270-9. PMID: 22891211
- LXR activation by GW3965 alters fat tissue distribution and adipose tissue inflammation in ob/ob female mice. | Archer, A., et al. 2013. J Lipid Res. 54: 1300-11. PMID: 23446231
- Action mechanisms of Liver X Receptors. | Gabbi, C., et al. 2014. Biochem Biophys Res Commun. 446: 647-50. PMID: 24300092
- Liver X Receptor Agonist GW3965 Regulates Synaptic Function upon Amyloid Beta Exposure in Hippocampal Neurons. | Báez-Becerra, C., et al. 2018. Neurotox Res. 33: 569-579. PMID: 29297151
- Modulation of long-chain Acyl-CoA synthetase on the development, lipid deposit and cryosurvival of in vitro produced bovine embryos. | Valente, RS., et al. 2019. PLoS One. 14: e0220731. PMID: 31381602
- Characterization of an Antibacterial Agent Targeting Ferrous Iron Transport Protein FeoB against Staphylococcus aureus and Gram-Positive Bacteria. | Shin, M., et al. 2021. ACS Chem Biol. 16: 136-149. PMID: 33378170
Inhibitor of:
Angptl5, apoH, C/EBP β, Ces1a, cHMGCS, INSIG-2, Kruppel, LRIF, NPC Marker, NRIP2, and ORP-7_Osbpl7.Activator of:
ABCD3, ABCG1, ABCG5, ACAT-2, ACBP, ACOXL, apoA-I, ATP-binding cassette sub-family A (ABCA), B42, Ces1a, Cypt2, DAF-12, Dbil5, EG545948, ERR beta, ERR gamma, GRAMD1A, HCNP, KCNQ1, LENG4, LXR alpha, LXR beta, MFSD6, NPC2, NR5A2, ORP-2, ORP-5, RANKL, SDSL, StARD6, ZIP-kinase, and ZNF768.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GW 3965 hydrochloride, 5 mg | sc-224011 | 5 mg | $137.00 | |||
GW 3965 hydrochloride, 25 mg | sc-224011A | 25 mg | $474.00 | |||
GW 3965 hydrochloride, 1 g | sc-224011B | 1 g | $3060.00 |