Molecular structure of GW 0742, CAS Number: 317318-84-6
GW 0742 (CAS 317318-84-6)
See product citations (11)
Alternate Names:
4-[[[2-[3-Fluoro-4-(trifluoromethyl)phenyl]-4-methyl-5-thiazolyl]methyl]thio]-2-methylphenoxy] Acetic Acid
Application:
GW 0742 is a potent and highly selective PPARβ agonist
CAS Number:
317318-84-6
Purity:
≥98%
Molecular Weight:
471.49
Molecular Formula:
C21H17F4NO3S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
GW 0742 is extensively used in research focusing on its activity as a selective peroxisome proliferator-activated receptor (PPAR) agonist, particularly targeting the PPAR-δ subtype. This compound is valuable for studies aimed at understanding the regulation of lipid metabolism and energy homeostasis. Researchers employ GW 0742 to investigate its role in enhancing endurance and metabolic rate, which contributes to insights into potential applications for increasing physical performance. Additionally, GW 0742 is used to explore its effects on inflammatory processes and insulin sensitivity, examining how activation of PPAR-δ influences these physiological responses. The research involving GW 0742 also extends to studying its impact on gene expression related to metabolism and inflammation.
GW 0742 (CAS 317318-84-6) References
- Effect of the peroxisome proliferator-activated receptor beta activator GW0742 in rat cultured cerebellar granule neurons. | Smith, SA., et al. 2004. J Neurosci Res. 77: 240-9. PMID: 15211590
- In vivo activation of peroxisome proliferator-activated receptor-delta protects the heart from ischemia/reperfusion injury in Zucker fatty rats. | Yue, TL., et al. 2008. J Pharmacol Exp Ther. 325: 466-74. PMID: 18287212
- Effects of the PPAR-beta agonist GW501516 in an in vitro model of brain inflammation and antibody-induced demyelination. | Defaux, A., et al. 2009. J Neuroinflammation. 6: 15. PMID: 19422681
- Involvement of Fatty Acid Binding Protein 5 and PPARβ/Δ in Prostate Cancer Cell Growth. | Morgan, E., et al. 2010. PPAR Res. 2010: PMID: 20847935
- GW0742, a high affinity PPAR-β/Δ agonist reduces lung inflammation induced by bleomycin instillation in mice. | Galuppo, M., et al. 2010. Int J Immunopathol Pharmacol. 23: 1033-46. PMID: 21244753
- Differential regulation of stimulated glucose transport by free fatty acids and PPARα or -Δ agonists in cardiac myocytes. | Asrih, M., et al. 2012. Am J Physiol Endocrinol Metab. 302: E872-84. PMID: 22297301
- The nuclear receptor PPARs as important regulators of T-cell functions and autoimmune diseases. | Choi, JM. and Bothwell, AL. 2012. Mol Cells. 33: 217-22. PMID: 22382683
- Peroxisome proliferator-activated receptor delta protects against obesity-related glomerulopathy through the P38 MAPK pathway. | Yan, Z., et al. 2013. Obesity (Silver Spring). 21: 538-45. PMID: 23592661
- A selective peroxisome proliferator-activated receptor-β/Δ agonist attenuates neointimal hyperplasia after wire-mediated arterial injury. | Hamaya, R., et al. 2013. Expert Opin Investig Drugs. 22: 1095-106. PMID: 23915387
- PPARβ activation restores the high glucose-induced impairment of insulin signalling in endothelial cells. | Quintela, AM., et al. 2014. Br J Pharmacol. 171: 3089-102. PMID: 24527778
- Peroxisome proliferator-activated receptors α and γ are linked with alcohol consumption in mice and withdrawal and dependence in humans. | Blednov, YA., et al. 2015. Alcohol Clin Exp Res. 39: 136-45. PMID: 25516156
- Regulation of the orexigenic neuropeptide, enkephalin, by PPARΔ and fatty acids in neurons of the hypothalamus and forebrain. | Poon, K., et al. 2015. J Neurochem. 135: 918-31. PMID: 26332891
- Combined pharmacological activation of AMPK and PPARΔ potentiates the effects of exercise in trained mice. | Manio, MC., et al. 2016. Physiol Rep. 4: PMID: 26997622
- GQ-130, a novel analogue of thiazolidinedione, improves obesity-induced metabolic alterations in rats: Evidence for the involvement of PPARβ/Δ pathway. | Silva, OA., et al. 2020. Clin Exp Pharmacol Physiol. 47: 798-808. PMID: 31909493
- Sphingosine 1-phosphate receptor 2 promotes erythrocyte clearance by vascular smooth muscle cells in intraplaque hemorrhage through MFG-E8 production. | Pan, D., et al. 2022. Cell Signal. 98: 110419. PMID: 35905868
Inhibitor of:
C/EBP δ, C6orf183, EG623459, EXOSC2, Heat shock protein family A (Hsp70), and OR6P1.Activator of:
ATF-5, B42, CEACAM1, CYP4A1, FADS2, FGF-19, MBP, Myelin P2, NKG2-D, Nur77, Nurr1, PPAR beta, PSM, Slfn3, StARD5, and TRAP.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GW 0742, 10 mg | sc-203991 | 10 mg | $190.00 | |||
GW 0742, 50 mg | sc-203991A | 50 mg | $815.00 |