Molecular structure of Guanosine 5′-O-(3-thiotriphosphate) tetralithium salt, CAS Number: 94825-44-2
Guanosine 5′-O-(3-thiotriphosphate) tetralithium salt (CAS 94825-44-2)
Alternate Names:
GTP-γ-S 4Li
Application:
Guanosine 5′-O-(3-thiotriphosphate) tetralithium salt is a G-protein-activating GTP analog
CAS Number:
94825-44-2
Molecular Weight:
562.98
Molecular Formula:
C10H12N5O13P3S•4Li
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Guanosine 5′-O-(3-thiotriphosphate) tetralithium salt is a compound that functions as a non-hydrolyzable analog of GTP, which is commonly used in research to study GTP-binding proteins and their cellular signaling pathways. Guanosine 5′-O-(3-thiotriphosphate) tetralithium salt may act by competitively binding to the active site of GTP-binding proteins, preventing the hydrolysis of GTP to GDP and thereby disrupting the normal function of these proteins. By doing so, it allows the study of specific roles of GTP-binding proteins in various cellular processes, such as cell growth, differentiation, and intracellular signaling. Additionally, the tetralithium salt form of guanosine 5′-O-(3-thiotriphosphate) provides enhanced solubility and stability, making it a useful tool for in vitro studies of GTP-binding protein function. Overall, this compound serves as a valuable research tool for elucidating the molecular mechanisms underlying cellular signaling pathways and related biological processes.
Guanosine 5′-O-(3-thiotriphosphate) tetralithium salt (CAS 94825-44-2) References
- Activation of a PTX-insensitive G protein is involved in histamine-induced recombinant M-channel modulation. | Guo, J. and Schofield, GG. 2002. J Physiol. 545: 767-81. PMID: 12482885
- Intracellular application of guanosine-5'-O-(3-thiotriphosphate) induces exocytotic granule fusion in guinea pig eosinophils. | Nüsse, O., et al. 1990. J Exp Med. 171: 775-86. PMID: 2137856
- Carbachol in the presence of guanosine 5'-O-(3-thiotriphosphate) stimulates the breakdown of exogenous phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 4-phosphate, and phosphatidylinositol by rat brain membranes. | Claro, E., et al. 1989. J Biol Chem. 264: 18288-95. PMID: 2553703
- Guanosine-5'-O-(3-thiotriphosphate) modifies kinetics of voltage-dependent calcium current in chick sensory neurons. | Marchetti, C. and Robello, M. 1989. Biophys J. 56: 1267-72. PMID: 2558735
- Guanosine 5'-O-(3-thiotriphosphate) reduces ADP-ribosylation of the inhibitory guanine nucleotide-binding regulatory protein of adenylyl cyclase (Ni) by pertussis toxin without causing dissociation of the subunits of Ni. Evidence of existence of heterotrimeric pt+ and pt- conformations of Ni. | Mattera, R., et al. 1987. J Biol Chem. 262: 11247-51. PMID: 3112155
- Induction of neurite formation in PC12 cells by microinjection of proto-oncogenic Ha-ras protein preincubated with guanosine-5'-O-(3-thiotriphosphate). | Satoh, T., et al. 1987. Mol Cell Biol. 7: 4553-6. PMID: 3325827
- Guanosine 5'-O-(3-thiotriphosphate) as an analog of GTP in protein biosynthesis. The effects of temperature and polycations on the accuracy of initial recognition of aminoacyl-tRNA ternary complexes by ribosomes. | Karim, AM. and Thompson, RC. 1986. J Biol Chem. 261: 3238-43. PMID: 3512549
- Evidence that a beta-adrenergic receptor-associated guanine nucleotide regulatory protein conveys guanosine 5'-O-(3-thiotriphosphate)- dependent adenylate cyclase activity. | Stadel, JM., et al. 1981. J Biol Chem. 256: 8718-23. PMID: 6267049
- Guanosine 5'-O-(3-thiotriphosphate), a potent nucleotide inhibitor of microtubule assembly. | Hamel, E. and Lin, CM. 1984. J Biol Chem. 259: 11060-9. PMID: 6381495
- Guanosine 5'-O-(3-thiotriphosphate) inhibits capping of reovirus mRNA. | Reeve, AE., et al. 1982. J Biol Chem. 257: 7018-22. PMID: 7045100
- Parthenogenetic activation of porcine oocytes with guanosine-5'-O-(3'-thiotriphosphate). | Macháty, Z., et al. 1995. Biol Reprod. 52: 753-8. PMID: 7779997
- Combination of arachidonic acid and guanosine 5'-O-(3-thiotriphosphate) induce translocation of rac p21s to membrane and activation of NADPH oxidase in a cell-free system. | Sawai, T., et al. 1993. Biochem Biophys Res Commun. 195: 264-9. PMID: 8395827
- Ligand-independent GLUT4 translocation induced by guanosine 5'-O-(3-thiotriphosphate) involves tyrosine phosphorylation. | Haruta, T., et al. 1998. Endocrinology. 139: 358-64. PMID: 9421434
- Guanosine 5'-O-(3-thiotriphosphate) (GTPgammaS) stimulation of GLUT4 translocation is tyrosine kinase-dependent. | Elmendorf, JS., et al. 1998. J Biol Chem. 273: 13289-96. PMID: 9582374
Inhibitor of:
ARL16, Gγ 11, Gγ 13, Gγ 9, G3BP, GBP8, Gm1527, Gm1966, Olfr1086, P2RY8, PLC-XD1, Rab 3C, Rab 43, Rabaptin-5β, RASAL2, RGL3, RGS20, RIP/Rab, SEC24A, and Slac2-c.Activator of:
α-Adaptin, 4931406P16Rik, 6720456B07Rik, A430078G23Rik, Amphiphysin I, ARHGAP25, ARHGEF17, ARHGEF37, ARL10, ARL15, ARL17, ARL3, ARL4D, ARL6IP6, ARL9, Arylsulfatase G, ASPHD1, Atlastin-2, BAI-1, BET5, BIG2, BIG3, C14orf73, C3orf54, C8γ, C8orf80, CDCrel-1, CdGAP, CED-2, D-GPCR, DDEF2, DENND5B, EHD2, EphA3, ERGIC-1, ERGIC-2, FGD5, Fibrocystin, Frabin, G β, Gα gust, Gγ 1, Gγ 10, GARNL3, GGTase-IIβ, Gm1527, Gm600, Gm949, golgin 45, Gpa1, GPR113, GPR162, GPR37L1, GPR97, GPSN2, GRK 1, GSG1, GTPBP1, HMP19, Intersectin, KIAA0895L_4931428F04Rik, KIAA1244, KIAA1539, Kir3, Latrophilin-2, Lfc, LOC147710, LRRC25, MKS3, MRCKα, N-WASP, nm23-M6, Olfr1100, Olfr466, Olfr871, Olfr995, Olfr996, Olr403, Olr840, OR1D5, OR1E2, OR1J1, OR1J4, OR1L1, OR1L6, OR1N1, OR1N2, OR2A42, OR5C1, PACSIN3, PDZ-GEF1, PIP5KIII, PITPNC1, PLC ζ, PLC 2, PLC-XD1, PLEKHG1, PLEKHG3, PRK1, Rab 15, RAb 19B, Rab 25, Rab 3 GAP p150, Rab 30, Rab 32, Rab 33B, Rab 34, Rab 37, Rab 39B, Rab 3D, Rab 40C, Rab 4A, Rab L2B, RAB3IL1, Rab40B, RAB6IP1, rabphilin-11, rabphilin-3AL, RAIN, Ral BP-1, Ran BP-3L, Rap 2B, RAP1, Ras-GRF1, RASEF, RASGEF1B, RasGRP2, RGP1, RGS14, Rho D, Rho F, Rho J, RIC-8A, RIC-8B, RILP, RIN3, RINL, RUFY2, SCYL1BP1, Sec15B, SEC16L, SEC22C, Sec31B, Synapsin IIIa, Synaptotagmin II, TGaseZ, TRAPPC6B, TRPC4, Unc79, v-SNARE Vti1a, V1RA, V1rg10, VAMP-2, VAMP-5, VIPAR, Vmn1r116, Vmn1r139, Vmn1r157, Vmn1r163, and Vmn2r29.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Guanosine 5′-O-(3-thiotriphosphate) tetralithium salt, 10 mg | sc-202639 | 10 mg | $465.00 |