Molecular structure of Guanosine 5′-O-(2-Thiodiphosphate) trilithium salt, CAS Number: 97952-36-8
Guanosine 5′-O-(2-Thiodiphosphate) trilithium salt (CAS 97952-36-8)
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Alternate Names:
GDP-Beta-S Trilithium Salt; Guanosine 5′-[β-thio]diphosphate trilithium salt
Application:
Guanosine 5′-O-(2-Thiodiphosphate) trilithium salt is a GDP analog that inhibits G-protein activation
CAS Number:
97952-36-8
Purity:
≥85%
Molecular Weight:
477.07
Molecular Formula:
C10H12N5O10P2S•3Li
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Guanosine 5′-O-(2-Thiodiphosphate) trilithium salt compound serves as a substrate in enzymatic reactions, including DNA and RNA polymerase-catalyzed synthesis. Furthermore, it plays a pivotal role in investigating enzyme kinetics and the regulation of gene expression. Additionally, 5′-GMP has proven to be useful in studying the impact of mutations on gene expression.
Guanosine 5′-O-(2-Thiodiphosphate) trilithium salt (CAS 97952-36-8) References
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- Two distinct signaling pathways upregulate NMDA receptor responses via two distinct metabotropic glutamate receptor subtypes. | Benquet, P., et al. 2002. J Neurosci. 22: 9679-86. PMID: 12427823
- A novel chloride conductance activated by extracellular ATP in mouse parotid acinar cells. | Arreola, J. and Melvin, JE. 2003. J Physiol. 547: 197-208. PMID: 12562938
- A Ric8/synembryn homolog promotes Gpa1 and Gpa2 activation to respectively regulate cyclic AMP and pheromone signaling in Cryptococcus neoformans. | Gong, J., et al. 2014. Eukaryot Cell. 13: 1290-9. PMID: 25084863
- Evidence of GTP-binding protein regulation of phospholipase A2 activity in isolated human platelet membranes. | Silk, ST., et al. 1989. J Biol Chem. 264: 21466-9. PMID: 2513318
- GABAB receptor attenuation of GABAA currents in neurons of the mammalian central nervous system. | Shen, W., et al. 2017. Physiol Rep. 5: PMID: 28348006
- Dissociation of bradykinin-induced prostaglandin formation from phosphatidylinositol turnover in Swiss 3T3 fibroblasts: evidence for G protein regulation of phospholipase A2. | Burch, RM. and Axelrod, J. 1987. Proc Natl Acad Sci U S A. 84: 6374-8. PMID: 2888113
- RE1-silencing transcription factor controls the acute-to-chronic neuropathic pain transition and Chrm2 receptor gene expression in primary sensory neurons. | Zhang, J., et al. 2018. J Biol Chem. 293: 19078-19091. PMID: 30327427
- G proteins: transducers of receptor-generated signals. | Gilman, AG. 1987. Annu Rev Biochem. 56: 615-49. PMID: 3113327
- High-Frequency Activation of Nucleus Accumbens D1-MSNs Drives Excitatory Potentiation on D2-MSNs. | Francis, TC., et al. 2019. Neuron. 103: 432-444.e3. PMID: 31221559
- Vasoactive intestinal polypeptide modulation of nicotinic ACh receptor channels in rat intracardiac neurones. | Cuevas, J. and Adams, DJ. 1996. J Physiol. 493 (Pt 2): 503-15. PMID: 8782112
- Resting membrane properties of locust muscle and their modulation I. Actions of the neuropeptides YGGFMRFamide and proctolin. | Walther, C., et al. 1998. J Neurophysiol. 80: 771-84. PMID: 9705468
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Guanosine 5′-O-(2-Thiodiphosphate) trilithium salt, 1 mg | sc-295029 | 1 mg | $136.00 | |||
Guanosine 5′-O-(2-Thiodiphosphate) trilithium salt, 5 mg | sc-295029A | 5 mg | $176.00 |