Guanosine 3′5′-cyclic Monophosphate, Sodium Salt (CAS 40732-48-7)
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Guanosine 3′5′-cyclic Monophosphate, also known as cGMP, is an important intracellular second messenger that may act to interact with the extracellular signals nitric oxide and natriuretic peptides, as well as mediate their action. Guanosine 3′5′-cyclic Monophosphate interacts with the receptors cGMP-dependent protein kinases, cGMP-regulated channels, and cGMP-regulated cyclic nucleotide phosphodiesterases. The compound can activate protein kinase G, and it has been shown that elevated levels of Guanosine 3′5′-cyclic Monophosphate in vivo stimulates cGMP-dependent protein kinase (PKG). Research shows that Guanosine 3′5′-cyclic Monophosphate can suppress apoptosis in rat ovarian follicles, and that it is metabolized quickly in the presence of corresponding phosphodiesterases.
Guanosine 3′5′-cyclic Monophosphate, Sodium Salt (CAS 40732-48-7) References
- Role of cGMP and Ca2+ in vertebrate photoreceptor excitation and adaptation. | Kaupp, UB. and Koch, KW. 1992. Annu Rev Physiol. 54: 153-75. PMID: 1314038
- Cyclic GMP metabolism and involvement in biological regulation. | Goldberg, ND. and Haddox, MK. 1977. Annu Rev Biochem. 46: 823-96. PMID: 20041
- Urinary excretion of guanosine 3':5'-cyclic monophosphate during sleep in obstructive sleep apnoea patients with and without nasal continuous positive airway pressure treatment. | Krieger, J., et al. 1989. Clin Sci (Lond). 76: 31-7. PMID: 2537703
- Linolenic Acid Attenuates the Vasodilation Induced by Acetylcholine in Isolated Rat Aortae. | Lee, SH., et al. 2019. Dose Response. 17: 1559325819894148. PMID: 31839761
- Interleukin-1 beta suppresses apoptosis in rat ovarian follicles by increasing nitric oxide production. | Chun, SY., et al. 1995. Endocrinology. 136: 3120-7. PMID: 7540548
- Signalling by cGMP-dependent protein kinases. | Vaandrager, AB. and de Jonge, HR. Mol Cell Biochem. 157: 23-30. PMID: 8739225
- Cyclic nucleotide-gated ion channels: an extended family with diverse functions. | Finn, JT., et al. 1996. Annu Rev Physiol. 58: 395-426. PMID: 8815801
- Structure and function of cyclic nucleotide-gated channels. | Zagotta, WN. and Siegelbaum, SA. 1996. Annu Rev Neurosci. 19: 235-63. PMID: 8833443
- Cyclic GMP-dependent protein kinase and cellular signaling in the nervous system. | Wang, X. and Robinson, PJ. 1997. J Neurochem. 68: 443-56. PMID: 9003029
- Distinct and specific functions of cGMP-dependent protein kinases. | Lohmann, SM., et al. 1997. Trends Biochem Sci. 22: 307-12. PMID: 9270304
- Activation of p38 mitogen-activated protein kinase by lipopolysaccharide in human neutrophils requires nitric oxide-dependent cGMP accumulation. | Browning, DD., et al. 1999. J Biol Chem. 274: 537-42. PMID: 9867877
- Direct high affinity modulation of connexin channel activity by cyclic nucleotides. | Bevans, CG. and Harris, AL. 1999. J Biol Chem. 274: 3720-5. PMID: 9920924
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Guanosine 3′5′-cyclic Monophosphate, Sodium Salt, 25 mg | sc-202172 | 25 mg | $42.00 |